THE SCOPE, CAUSE AND CONSEQUENCES OF AGE-RELATED DECLINE IN NEURAL DISTINCTIVENESS AND BRAIN SIGNAL VARIABI…
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ASST_NON_K00AG068517_075 · UNIVERSITY OF CALIFORNIA IRVINE · Department of Health and Human Services
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- Assistance award identifier
- ASST_NON_K00AG068517_075
- FAIN
- K00AG068517
- Recipient
- UNIVERSITY OF CALIFORNIA IRVINE
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $307,606
- Period
- Sep 1, 2020 – Aug 31, 2026
- Fiscal year
- 2022
- Place of performance state
- CA
- Source file
- FY2022_All_Assistance_Full_20261006.zip
Description
THE SCOPE, CAUSE AND CONSEQUENCES OF AGE-RELATED DECLINE IN NEURAL DISTINCTIVENESS AND BRAIN SIGNAL VARIABILITY IN HEALTHY AND PATHOLOGICAL AGING - NORMAL AGING IS TYPICALLY ASSOCIATED WITH PERVASIVE DECLINES IN COGNITIVE, MOTOR AND SENSORY FUNCTION; HOWEVER, THERE ARE SUBSTANTIAL INDIVIDUAL DIFFERENCES: SOME OLDER ADULTS EXPERIENCE MILD IMPAIRMENTS WHILE OTHERS EXPERIENCE SEVERE COGNITIVE DECLINES. UNDERSTANDING THE NEURAL BASES OF INDIVIDUAL DIFFERENCES DURING AGING IS IMPERATIVE IN DESIGNING FUTURE INTERVENTIONS TO ADDRESS AGE-RELATED COGNITIVE IMPAIRMENTS. USING BEHAVIORAL TESTING, FUNCTIONAL MRI, SPECTROSCOPY AND PHARMACOLOGICAL MANIPULATIONS IN HUMAN ADULTS, I PROPOSE TO INVESTIGATE THE SCOPE, CAUSE AND CONSEQUENCES OF AGE-RELATED DECLINE IN TWO NEURAL FACTORS THAT MAY PLAY A ROLE IN THESE INDIVIDUAL DIFFERENCES: (1) NEURAL DISTINCTIVENESS (HOW SIMILAR/CONFUSABLE NEURAL ACTIVATION PATTERNS ARE IN RESPONSE TO DIFFERENT STIMULUS CATEGORIES) AND (2) BRAIN SIGNAL VARIABILITY (MOMENT-TO-MOMENT CHANGE IN NEURAL ACTIVITY INDEPENDENT OF TASK). BOTH THESE MEASURES HAVE BEEN FOUND TO DECLINE WITH AGE AND BOTH HAVE BEEN ASSOCIATED WITH INDIVIDUAL DIFFERENCES IN BEHAVIOR. DURING THE PREDOCTORAL (F99) PHASE OF THE TRAINING, MY RESEARCH WILL FOCUS ON HEALTHY AGING: 1) INVESTIGATING THE SCOPE AND CAUSE (SPECIFICALLY ROLE OF GABA LEVELS) OF AGE-RELATED DECLINE IN NEURAL DISTINCTIVENESS IN SENSORY REGIONS, 2) THE CAUSE OF AGE-RELATED DECLINES IN BRAIN SIGNAL VARIABILITY, AND 3) THE BEHAVIORAL CONSEQUENCES OF AGE-RELATED DECLINES IN THESE TWO NEURAL MEASURES. DURING THE POSTDOCTORAL (K00) PHASE, I WILL EXTEND MY PREVIOUS RESEARCH TO AGAIN STUDY NEURAL DISTINCTIVENESS AND BRAIN SIGNAL VARIABILITY, BUT NOW IN THE CONTEXT OF MEMORY AND HIPPOCAMPAL DYSFUNCTION, AND IN A CLINICAL POPULATION (PATIENTS WITH MILD COGNITIVE IMPAIRMENT, MCI). I WILL USE TASK-BASED FMRI TO MEASURE NEURAL DISTINCTIVENESS, RESTING-STATE FMRI TO MEASURE BRAIN SIGNAL VARIABILITY, AND MR SPECTROSCOPY TO MEASUR