CONCURRENT TRAJECTORIES OF PHYSICAL FRAILTY AND COGNITIVE IMPAIRMENT AMONG NURSING HOME RESIDENTS AND COMMU…

Assistance award details

Assistance award identifier

ASST_NON_K00AG068591_075

FAIN

K00AG068591

Recipient

UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL

Awarding agency

Department of Health and Human Services

Funding agency

Department of Health and Human Services

Assistance listing (CFDA)

93.866

Total obligated

$356,933

Period

Sep 1, 2020 – Jun 30, 2026

Fiscal year

2022

Place of performance state

MA

Source file

FY2022_All_Assistance_Full_20261006.zip

Description

CONCURRENT TRAJECTORIES OF PHYSICAL FRAILTY AND COGNITIVE IMPAIRMENT AMONG NURSING HOME RESIDENTS AND COMMUNITY-DWELLING OLDER ADULTS - PHYSICAL FRAILTY, CHARACTERIZED BY DECREASED PHYSIOLOGIC RESERVE AND INCREASED VULNERABILITY TO STRESSORS, AND COGNITIVE IMPAIRMENT, RANGING FROM MILD IMPAIRMENT TO DEMENTIA, OFTEN CO-OCCUR IN OLDER ADULTS. BOTH ARE ASSOCIATED WITH CONSIDERABLE ADVERSE HEALTH OUTCOMES, HIGH HEALTHCARE COSTS, AND SUBSTANTIAL CAREGIVER BURDEN, AND HIGHLY PREVALENT IN U.S. COMMUNITY-DWELLING OLDER ADULTS. HOWEVER, FOR OLDER ADULTS RECEIVING LONG-TERM CARE IN NURSING HOMES, DATA IS SCARCE ON THE PREVALENCE OF THE TWO CONDITIONS OVER THEIR STAY. COMMUNITY-BASED STUDIES SUGGEST HETEROGENEOUS CLINICAL PRESENTATION OF PHYSICAL FRAILTY, WHICH MAY HAVE IMPLICATIONS FOR ITS MANAGEMENT. IT IS UNKNOWN IF SUCH HETEROGENEITY IS SIMILAR IN OLDER NURSING HOME RESIDENTS AND IF IT IS INFLUENCED BY COGNITIVE IMPAIRMENT. FURTHER, PHYSICAL FRAILTY AND COGNITIVE IMPAIRMENT SHARE RISK FACTORS AND PREDICT FUTURE ONSET OF ONE ANOTHER BUT THE MECHANISM OF THIS COMPLEX INTERPLAY REMAINS UNCLEAR. LASTLY, DEPRESSION IS STRONGLY CORRELATED WITH BOTH CONDITIONS, YET FINDINGS REGARDING THE IMPACT OF ANTIDEPRESSANTS ON THE PROGRESSION OF PHYSICAL FRAILTY AND COGNITIVE IMPAIRMENT ARE INCONSISTENT. THIS PROPOSED F99/K00 PROJECT SEEKS TO ADDRESS THESE GAPS BY TWO SPECIFIC AIMS WITH POPULATION LONGITUDINAL DATA AND ADVANCED STATISTICAL METHODS. AIM 1 (DISSERTATION RESEARCH) FOCUSES ON OLDER NURSING HOME RESIDENTS AND WILL DESCRIBE THE PREVALENCE OF PHYSICAL FRAILTY AND COGNITIVE IMPAIRMENT; IDENTIFY SUBGROUPS OF PHYSICAL FRAILTY AND EXAMINE THE VARIATION OF SUBGROUPS BY COGNITIVE IMPAIRMENT LEVELS; AND DELINEATE THE DEVELOPMENTAL TRAJECTORIES OF PHYSICAL FRAILTY AND COGNITIVE IMPAIRMENT AND EXAMINE THE CORRELATIONS BETWEEN TRAJECTORIES. AIM 2 (POST-DOCTORAL RESEARCH) EXPANDS TO OLDER ADULTS IN THE COMMUNITY AND WILL ASSESS THE RECIPROCAL ASSOCIATION BETWEEN PHYSICAL FRAILTY AND COGNITIV