GENETIC AND ENVIRONMENTAL DRIVERS OF COGNITIVE RESILIENCE IN AGING POPULATIONS - PROJECT SUMMARY/ABSTRACT A…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
Assistance award details
- Assistance award identifier
- ASST_NON_K00AG073565_075
- FAIN
- K00AG073565
- Recipient
- WASHINGTON UNIVERSITY, THE
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $231,590
- Period
- Sep 1, 2021 – Aug 31, 2028
- Fiscal year
- 2024
- Place of performance state
- MO
- Source file
- FY2024_All_Assistance_Full_20261006.zip
Description
GENETIC AND ENVIRONMENTAL DRIVERS OF COGNITIVE RESILIENCE IN AGING POPULATIONS - PROJECT SUMMARY/ABSTRACT ALZHEIMER'S DISEASE AND RELATED DEMENTIAS (ADRD) ARE MAJOR SOURCES OF HEALTH, SOCIAL, AND ECONOMIC BURDEN. THE LACK OF EFFECTIVE ADRD THERAPIES OR STRATEGIES TO PREVENT OR STOP ADRD PROGRESSION PRESENTS A SIGNIFICANT PUBLIC HEALTH CHALLENGE IN THE CONTEXT OF AGING POPULATIONS. A FOCUS ON RESILIENCE, INSTEAD OF DISEASE, MAY PROVIDE INSIGHT INTO NOVEL TREATMENT AND PREVENTION MODALITIES. COGNITIVELY RESILIENT INDIVIDUALS TYPICALLY RETAIN NORMAL COGNITIVE FUNCTION DESPITE ADVANCED AGE OR BRAIN PATHOLOGY. THE GENETIC ARCHITECTURES OF COGNITIVE RESILIENCE AND ALZHEIMER'S DISEASE APPEAR DISTINCT BASED ON RECENT GENOMIC WORK. HOWEVER, FURTHER INTERROGATION OF THE BIOLOGIC BASIS OF COGNITIVE RESILIENCE, INCLUDING THE INTERPLAY BETWEEN GENETIC AND ENVIRONMENTAL FACTORS, IS NECESSARY TO DESIGN TARGETED INTERVENTIONS THAT BUILD COGNITIVE RESILIENCE IN OLDER ADULTS. WE POSIT THAT A MULTI-OMICS APPROACH CAN IDENTIFY NOVEL COGNITIVE RESILIENCE LOCI AND ELUCIDATE PATHWAYS THAT PROMOTE COGNITIVE RESILIENCE AND LOWER THE RISK OF ADRD. WE PROPOSE TO USE EXTANT GENOMIC DATA, HIGH- QUALITY LONGITUDINAL MEASUREMENTS OF 5,000 PLASMA PROTEINS, REPEAT PSYCHOMETRIC ASSESSMENTS, AND NEUROIMAGING IN THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY TO ACCOMPLISH THE FOLLOWING SPECIFIC AIMS: (1) EMPLOY A MULTI-OMIC APPROACH TO IDENTIFY CAUSAL LOCI AND BIOMARKERS FOR COGNITIVE RESILIENCE IN COMMUNITY-DWELLING OLDER ADULTS AND (2) DECOMPOSE THE GENETIC AND ENVIRONMENTAL DRIVERS OF COGNITIVE RESILIENCE. IN AIM 1, WE WILL CONDUCT A PROTEOME-WIDE ASSOCIATION STUDY (PWAS) TO IDENTIFY PROTEINS ASSOCIATED WITH COGNITIVE RESILIENCE. GIVEN HETEROGENEITY IN THE MEASURE OF COGNITIVE RESILIENCE IN EPIDEMIOLOGIC STUDIES, WE WILL USE PSYCHOMETRIC AND IMAGING-BASED DEFINITIONS OF COGNITIVE RESILIENCE. WE WILL ALSO IDENTIFY PROTEIN QUANTITATIVE TRAIT LOCI, PERFORM FINE-MAPPING, AND USE MENDELIAN RANDOMI