ASSOCIATIONS OF ADVERSE CHILDHOOD EXPERIENCES WITH MIDLIFE NEIGHBORHOOD DEPRIVATION AND COGNITIVE TRAJECTOR…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
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ASST_NON_K00AG083275_075 · UNIVERSITY OF WISCONSIN SYSTEM · Department of Health and Human Services
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- Assistance award identifier
- ASST_NON_K00AG083275_075
- FAIN
- K00AG083275
- Recipient
- UNIVERSITY OF WISCONSIN SYSTEM
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $169,601
- Period
- Sep 18, 2023 – May 31, 2029
- Fiscal year
- 2025
- Place of performance state
- WI
- Source file
- FY2025_All_Assistance_Full_20261006.zip
Description
ASSOCIATIONS OF ADVERSE CHILDHOOD EXPERIENCES WITH MIDLIFE NEIGHBORHOOD DEPRIVATION AND COGNITIVE TRAJECTORIES AND DEMENTIA OUTCOMES IN LATER LIFE - PROJECT SUMMARY THE BURDEN OF ALZHEIMERâS DISEASE AND RELATED DEMENTIAS (ADRD) IS PROJECTED TO INCREASE BY 150% BY THE YEAR 2060 TO AFFECT 14 MILLION AMERICANS, WITH FOUR- AND SEVEN-FOLD INCREASES ANTICIPATED AMONG BLACK AND HISPANIC/LATINO OLDER ADULTS. TO BETTER UNDERSTAND THE ACCUMULATION OF RISK THROUGHOUT THE LIFE COURSE AND THE DISPARITIES THAT EXIST IN ADRD, STUDYING SOCIAL AND STRUCTURAL DETERMINANTS OF HEALTH AND EMPLOYING A LIFE COURSE PERSPECTIVE HAVE BEEN EMPHASIZED. RESEARCH ON THE ROLE OF EARLY LIFE STRESSORS AND ADVERSITY ON ADRD IS EMERGING, BUT STILL LIMITED. OLDER ADULTS WHO EXPERIENCED MORE CHILDHOOD ADVERSITIES HAD GREATER LIKELIHOOD OF INCIDENT DEMENTIA IN THREE INTERNATIONAL AGING COHORTS; U.S.-BASED STUDIES HAVE BEEN LARGELY CROSS-SECTIONAL IN DESIGN, MIXED RESULTS HAVE BEEN OBSERVED, AND ONLY ONE EXAMINED RACIAL/ETHNIC DIFFERENCES. HOWEVER, GREATER UNDERSTANDING OF THE ROLE THESE FACTORS PLAY IS IMPERATIVE IF WE AIM TO MITIGATE THE RISK OF ADRD WITH A HEALTH EQUITY LENS. IDENTIFYING EARLY LIFE RISK FACTORS FOR ADRD AND THE PRIMARY PATHWAYS THROUGH WHICH CHILDHOOD ADVERSITY IS OPERATING WILL ALLOW FOR MORE TARGETED INTERVENTIONS TO REDUCE RISK OF ADRD IN LATER LIFE FOR THE MOST VULNERABLE IN OUR POPULATION. IN ADDITION, THE ROLE OF NEIGHBORHOOD DEPRIVATION IN THESE RELATIONSHIPS REMAINS UNDERSTUDIED, DESPITE KNOWN RAMIFICATIONS OF ENVIRONMENTAL FACTORS ON HEALTH BEHAVIORS AND OUTCOMES. UNDERSTANDING STRUCTURAL DETERMINANTS OF HEALTH AND HOW THEY IMPACT RISK OF ADRD WILL PROVIDE VALUABLE INSIGHT FOR IDENTIFYING THE MOST VULNERABLE COMMUNITIES FOR TARGETING EFFECTIVE PREVENTION STRATEGIES AND MOTIVE FOR STRUCTURAL CHANGES AND POLICIES THAT AIM TO IMPROVE THESE ENVIRONMENTS AND THE OVERALL HEALTH OF THOSE INDIVIDUALS AT GREATEST RISK. TO HAVE THE GREATEST IMPACT ON REDUCING THE RISK OF ADRD, THE RO