SEX-SPECIFIC IMPACT OF STROKE ON NEUROMUSCULAR FATIGABILITY IN OLDER ADULTS - PROJECT SUMMARY/ABSTRACT AGIN…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
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ASST_NON_K00AG083283_075 · UNIVERSITY OF WISCONSIN SYSTEM · Department of Health and Human Services
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- Assistance award identifier
- ASST_NON_K00AG083283_075
- FAIN
- K00AG083283
- Recipient
- UNIVERSITY OF WISCONSIN SYSTEM
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $169,984
- Period
- Mar 6, 2024 – May 31, 2029
- Fiscal year
- 2025
- Place of performance state
- WI
- Source file
- FY2025_All_Assistance_Full_20261006.zip
Description
SEX-SPECIFIC IMPACT OF STROKE ON NEUROMUSCULAR FATIGABILITY IN OLDER ADULTS - PROJECT SUMMARY/ABSTRACT AGING IS A NON-MODIFIABLE RISK FACTOR OF STROKE. NOTABLY, FEMALES ARE MORE LIKELY TO EXPERIENCE A STROKE AT AN OLDER AGE AND TEND TO HAVE WORSE RECOVERY OUTCOMES THAN MALES POST STROKE, ESPECIALLY IN MOTOR RECOVERY. IN ADDITION TO BASELINE WEAKNESS, INCREASED NEUROMUSCULAR FATIGABILITY (AN ACUTE, EXERCISE-INDUCED REDUCTION IN MAXIMAL VOLUNTARY FORCE OR POWER GENERATION) OF THE PARETIC MUSCULATURE FOLLOWING A STROKE LIMITS TASK ENDURANCE OF ACTIVITIES SUCH AS WALKING. RECENTLY, OUR LABORATORY SHOWED THAT FATIGABILITY MAY BE EXACERBATED IN FEMALES, BUT NOT MALES, WITH STROKE AS COMPARED TO NEUROLOGICALLY INTACT CONTROLS DURING A SUSTAINED ISOMETRIC CONTRACTION. HOWEVER, LITTLE IS KNOWN REGARDING STROKE-RELATED SEX DIFFERENCES IN FATIGABILITY DURING DYNAMIC TASKS DESPITE THEIR GREATER RELEVANCE TO EVERYDAY ACTIVITIES LIKE WALKING. IN PEOPLE WITHOUT STROKE, OLDER FEMALES SHOW A RELATIVELY BLUNTED VASCULAR RESPONSE DURING DYNAMIC EXERCISE AND ARE MORE FATIGABLE THAN OLDER MALES, BUT IT IS UNKNOWN IF THIS PERSISTS POST STROKE. THE F99 PHASE RESEARCH AIMS TO QUANTIFY SEX DIFFERENCES IN FATIGABILITY DURING A DYNAMIC TASK POST STROKE AND EXAMINE THE ROLE OF SEX DIFFERENCES IN PERIPHERAL MUSCLE PERFUSION AS A MECHANISM. WE PROPOSE THAT IMPAIRED MUSCLE PERFUSION CONTRIBUTES TO THE GREATER FATIGABILITY DURING DYNAMIC KNEE EXTENSION CONTRACTIONS IN FEMALES VERSUS MALES WITH CHRONIC STROKE. IF MUSCLE PERFUSION IS A MECHANISM, THEN MANIPULATING BLOOD FLOW DURING EXERCISE WOULD MODULATE SEX DIFFERENCES IN FATIGABILITY AMONG PEOPLE WITH CHRONIC STROKE. AIM 1 WILL TEST THE HYPOTHESIS THAT FEMALES WILL HAVE GREATER FATIGABILITY THAN MALES POST STROKE AND THAT FATIGABILITY WILL BE NEGATIVELY CORRELATED WITH THE METRICS OF BLOOD FLOW TO THE EXERCISING MUSCULATURE. AIM 2 WILL TEST THE HYPOTHESIS THAT SEX DIFFERENCES IN FATIGABILITY POST STROKE WILL BE LESSENED DURING THE SAME EXERCISE W