THE IMPACT OF SARS-COV-2 INFECTION AND VACCINATION ON THE RISK OF ALZHEIMERâS DISEASE AND RELATED DEMENTI…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
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ASST_NON_K00AG083306_075 · PRESIDENT AND FELLOWS OF HARVARD COLLEGE · Department of Health and Human Services
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- Assistance award identifier
- ASST_NON_K00AG083306_075
- FAIN
- K00AG083306
- Recipient
- PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $174,241
- Period
- Dec 1, 2023 – May 31, 2029
- Fiscal year
- 2025
- Place of performance state
- MA
- Source file
- FY2025_All_Assistance_Full_20261006.zip
Description
THE IMPACT OF SARS-COV-2 INFECTION AND VACCINATION ON THE RISK OF ALZHEIMERâS DISEASE AND RELATED DEMENTIAS - PROJECT SUMMARY/ABSTRACT THE GROWING PREVALENCE OF ALZHEIMERâS DISEASE AND ALZHEIMERâS RELATED DISORDERS (ADRD) IS A CRITICAL PUBLIC HEALTH CONCERN, POTENTIALLY EXACERBATED BY THE COVID-19 PANDEMIC. INFECTIOUS DISEASES MAY INCREASE ADRD RISK BY CAUSING NEUROINFLAMMATION AND OXIDATIVE DAMAGE IN THE CENTRAL NERVOUS SYSTEM, PROMOTING ATHEROSCLEROSIS AND ENDOTHELIAL DYSFUNCTION, OR VIA OTHER INFLAMMATORY, IMMUNE-RESPONSE, AND VASCULAR MECHANISMS. DESPITE INTRIGUING LINKS BETWEEN SEVERAL INFECTIOUS AND NEURODEGENERATIVE CONDITIONS, WHETHER AND HOW INFECTIOUS DISEASES INFLUENCE ADRD RISK REMAINS UNDEREXPLORED. THIS QUESTION IS URGENT ESPECIALLY DURING THE COVID-19 PANDEMIC, WHERE THE WIDESPREAD SARS-COV-2 INFECTION HAS HEAVILY IMPACTED GLOBAL PUBLIC HEALTH. MOUNTING EVIDENCE SUGGESTS A SIGNIFICANT FRACTION OF THOSE INFECTED WITH SARS-COV-2 MAY EXPERIENCE SUBSTANTIAL AND LONG-LASTING SEQUELAE, INCLUDING COGNITIVE DECLINE AND NEUROLOGIC DEFICITS. MANY UNKNOWNS REMAIN, INCLUDING LONG-TERM OUTCOMES AND THE ROLE OF COVID-19 VACCINATION AND VIRAL VARIANTS IN MODIFYING THE EFFECT OF SARS-COV-2 INFECTION ON COGNITIVE DECLINE AND ADRD RISK. THIS PROPOSED F99/K00 PROJECT SEEKS TO ADDRESS THESE GAPS WITH TWO SPECIFIC AIMS USING COMPLEMENTARY LONGITUDINAL DATASETS AND RIGOROUS, ADVANCED EPIDEMIOLOGICAL AND STATISTICAL METHODS. AIM 1 (F99 DISSERTATION PHASE: 2023-2025) WILL USE THE PREVIOUSLY IDENTIFIED COVID-19 BRAIN MAGNETIC RESONANCE IMAGING (MRI) SIGNATURE REGION TO INFER THE LONG-TERM EFFECTS OF INFECTION ON ADRD RISK VIA BRAIN STRUCTURE CHANGES. THE COVID-19 MRI SIGNATURE REGION COMPRISES BRAIN REGIONS WHERE CORTICAL THICKNESS AND GRAY-WHITE MATTER CONTRAST WAS REDUCED AFTER SARS- COV-2 INFECTION (IDENTIFIED IN A LONGITUDINAL MRI STUDY). THE CANDIDATE WILL QUANTIFY THE ASSOCIATION BETWEEN THE COVID-19 MRI SIGNATURE REGION AND FUTURE ADRD RISK AMONG UK BIOBANK PARTI