COGNITIVE PROGRESSION AMONG OLDER ADULTS WITH SUBJECTIVE COGNITIVE DECLINE AND MILD COGNITIVE IMPAIRMENT: T…

Assistance award details

Assistance award identifier

ASST_NON_K00AG088437_075

FAIN

K00AG088437

Recipient

SUTTER BAY HOSPITALS

Awarding agency

Department of Health and Human Services

Funding agency

Department of Health and Human Services

Assistance listing (CFDA)

93.866

Total obligated

$206,982

Period

Aug 22, 2024 – May 31, 2029

Fiscal year

2025

Place of performance state

CA

Source file

FY2025_All_Assistance_Full_20261006.zip

Description

COGNITIVE PROGRESSION AMONG OLDER ADULTS WITH SUBJECTIVE COGNITIVE DECLINE AND MILD COGNITIVE IMPAIRMENT: THE ROLES OF SLEEP AND PHYSICAL FRAILTY - PROJECT SUMMARY INDIVIDUALS WITH SUBJECTIVE COGNITIVE DECLINE (SCD) AND MILD COGNITIVE IMPAIRMENT (MCI) ARE SIGNIFICANTLY MORE LIKELY TO HAVE INCREASED AD BIOMARKERS (E.G. AMYLOID Β) AND HIGHER RISKS OF DEVELOPING ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (ADRD). SLEEP DISTURBANCES HAVE BEEN ASSOCIATED WITH INCREASED RISKS PRECLINICAL AD, ADRD, AND ALL-CAUSE DEMENTIA. HOWEVER, MOST OF THESE STUDIES FOCUS ON SLEEP’S ASSOCIATION WITH THE INCIDENCE OF SCD, MCI, OR DEMENTIA INDIVIDUALLY, RATHER THAN THE PROGRESSION OF COGNITIVE IMPAIRMENT FROM SCD TO MCI TO DEMENTIA. THE LATTER IS OF KEY CLINICAL IMPORTANCE WHEN ATTEMPTING TO HALT OR TREAT AD PROGRESSION. IN ADDITION TO SLEEP, RECENT STUDIES HAVE SHOWN THAT PHYSICAL FRAILTY IS ALSO CLOSELY INTERRELATED WITH COGNITIVE IMPAIRMENT, WITH EVIDENCE THAT THEY PREDICT ONE ANOTHER, SHARE COMMON RISK FACTORS, AND HAVE SIMILAR POTENTIAL MECHANISMS. THE CO-EXISTENCE OF BOTH PHYSICAL FRAILTY AND COGNITIVE IMPAIRMENT (MCI/SCD), ALSO KNOWN AS COGNITIVE FRAILTY, IS SUPPOSED TO BE A PREDICTOR OF SEVERE HEALTH CONSEQUENCES WITH THE SYNERGIC NEGATIVE EFFECTS OF BOTH. HOWEVER, THIS SYNERGIC EFFECT ON FUTURE COGNITIVE DECLINE AND PROGRESSION TO DEMENTIA IS STILL UNDEREXAMINED IN THE LITERATURE. MOREOVER, GIVEN THE INTERRELATIONSHIP BETWEEN PHYSICAL FRAILTY AND COGNITIVE IMPAIRMENT, IT IS POSSIBLE THAT PHYSICAL FRAILTY MODERATES THE ASSOCIATIONS BETWEEN SLEEP DISTURBANCES AND PROGRESSION FROM SCD/MCI TO DEMENTIA. THEREFORE, THE OVERALL GOAL OF THIS PROJECT IS TO INVESTIGATE THE ROLES OF SLEEP DISTURBANCES AND PHYSICAL FRAILTY IN SCD/MCI’S COGNITIVE PROGRESSION AND EXPLORE WHETHER PHYSICAL FRAILTY IS A MODERATOR OF SLEEP’S ASSOCIATION WITH THE COGNITIVE PROGRESSION. IN THE F99 PHASE, THE PI WILL USE SIX WAVES OF LONGITUDINAL HEALTH AND RETIREMENT STUDY DATA FROM THE 2010 TO 2020 TO EXAMIN