ASSOCIATION OF BLOOD-BRAIN BARRIER BREAKDOWN WITH BRAIN MICROSTRUCTURE NEUROPATHOLOGY IN EARLY ALZHEIMER'S…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
Research this with AI
Research smarter with AI
Analyze opportunities and compare insights across leading AI models.
ASST_NON_R00AG057797_075 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · Department of Health and Human Services
Compare Multiple AI Models with SmartSoloExplore CaptureIQ IntelligenceAssistance award details
- Assistance award identifier
- ASST_NON_R00AG057797_075
- FAIN
- R00AG057797
- Recipient
- UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $762,219
- Period
- Sep 1, 2021 – May 31, 2024
- Fiscal year
- 2021
- Place of performance state
- CA
- Source file
- FY2021_All_Assistance_Full_20261006.zip
Description
ASSOCIATION OF BLOOD-BRAIN BARRIER BREAKDOWN WITH BRAIN MICROSTRUCTURE NEUROPATHOLOGY IN EARLY ALZHEIMER'S DISEASE - PROJECT SUMMARY/ABSTRACT BACKGROUND: AS COGNITIVE DECLINE IS A MOUNTING HEALTH CONCERN FOR OUR AGING POPULATION, IT IS BECOMING INCREASINGLY IMPORTANT TO BETTER CHARACTERIZE THE NEUROBIOLOGICAL CHANGES LEADING TO AGE-RELATED COGNITIVE IMPAIRMENT AND DEMENTIA. ALTHOUGH NEUROIMAGING METHODS HAVE SHOWN PROMISE AT DETECTING MICROSTRUCTURAL BRAIN CHANGES ASSOCIATED WITH COGNITIVE DECLINE AND ALZHEIMER'S DISEASE (AD), THERE IS NEED FOR BIOMARKERS WITH IMPROVED SENSITIVITY TO THE EARLIEST DISEASE STAGES, WHEN TREATMENTS MAY BE MOST EFFECTIVE. EMERGING RESEARCH SUGGESTS THAT BLOOD-BRAIN BARRIER (BBB) BREAKDOWN OCCURS WHEN COGNITIVE IMPAIRMENTS ARE STILL MILD, AND MAY PRECEDE BRAIN ATROPHY. FURTHER RESEARCH IS NEEDED TO UNDERSTAND HOW BBB PERMEABILITY CHANGES OVER THE COURSE OF AD AND HOW IT RELATES TO ESTABLISHED MARKERS OF BRAIN MICROSTRUCTURE, MORPHOMETRY AND MOLECULAR PATHOLOGY. PRELIMINARY STUDIES: OUR PILOT STUDY DEMONSTRATED SENSITIVITY OF RESTRICTION SPECTRUM IMAGING (RSI) TO MICROSTRUCTURAL BRAIN CHANGES IN MILD COGNITIVE IMPAIRMENT (MCI) AND EARLY AD. RSI, COGNITIVE FUNCTION AND CSF AMYLOID-SS WERE MEASURED IN 31 HEALTHY CONTROLS (HC), 12 INDIVIDUALS WITH MCI AND 13 WITH MILD AD. NEURITE DENSITY (ND), A MEASURE OF RESTRICTED WATER DIFFUSION THAT ACCOUNTS FOR CROSSING FIBERS, WAS LOWER IN SEVERAL WHITE MATTER TRACTS, AND GRAY MATTER ISOTROPIC FREE WATER DIFFUSION (IF) WAS HIGHER FOR MCI/AD THAN HC. ND AND IF CORRELATED WITH EPISODIC MEMORY AND WITH AMYLOID-SS BURDEN. PROPOSED STUDIES: DYNAMIC CONTRAST-ENHANCED MRI, RSI, STRUCTURAL MRI, CSF AMYLOID-SS AND TAU, AND NEUROPSYCHOLOGICAL DATA WILL BE ACQUIRED ON 15 HC WITH LOW GENETIC RISK FOR AD (APOE4 NON-CARRIERS) AND 15 INDIVIDUALS WITH MCI. BBB PERMEABILITY WILL BE COMPARED BETWEEN GROUPS AND CORRELATED WITH MEMORY PERFORMANCE, RSI MEASURES, MORPHOMETRY AND AMYLOID/TAU TO TEST WHETHER BBB BREAKDOWN IS