THE SEX SPECIFIC IMPACT OF ANXIETY ON ALZHEIMER'S DISEASE PROGRESSION - PROJECT SUMMARY / ABSTRACT FOR THIS…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
Assistance award details
- Assistance award identifier
- ASST_NON_R00AG059953_075
- FAIN
- R00AG059953
- Recipient
- ROSALIND FRANKLIN UNIVERSITY OF MEDICINE & SCIENCE
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $747,000
- Period
- Apr 1, 2022 – Mar 31, 2025
- Fiscal year
- 2022
- Place of performance state
- IL
- Source file
- FY2022_All_Assistance_Full_20261006.zip
Description
THE SEX SPECIFIC IMPACT OF ANXIETY ON ALZHEIMER'S DISEASE PROGRESSION - PROJECT SUMMARY / ABSTRACT FOR THIS K99/R00, I WILL SPECIFICALLY ADDRESS THE ROLE OF ANXIETY AND ANATOMICAL SEX ON ALZHEIMERâS DISEASE (AD) PROGRESSION, SPECIFICALLY MEMORY LOSS. AD, A DEBILITATING NEURODEGENERATIVE AND MENTAL DISORDER, STANDS ALONE AS ONE OF THE TEN LEADING CAUSES OF DEATH IN THE UNITED STATES THAT CANNOT BE PREVENTED, SLOWED, OR CURED. FURTHERMORE, NEUROPSYCHIATRIC DISTURBANCES, SUCH AS DEPRESSION AND ANXIETY, ARE OBSERVED IN 90% OF AD PATIENTS AND ARE FREQUENT IN THOSE AT RISK FOR AD. ALTHOUGH MOST AD STUDIES HAVE BEEN PERFORMED USING MALE MICE, RECENT EVIDENCE SUGGESTS THAT FEMALES ARE MORE SUSCEPTIBLE TO DEPRESSION, ANXIETY, AND AD WHEN COMPARED TO MALES. IN FACT, TWO-THIRDS OF AD PATIENTS ARE WOMEN. HERE, WE AIM TO IDENTIFY THE NEURAL ENSEMBLES LINKING ANXIETY AND MEMORY LOSS FOLLOWING AD PROGRESSION BY UTILIZING BEHAVIORAL STUDIES, OPTOGENETICS, WHOLE-BRAIN MICROSCOPY, AND IN VIVO CA2+ IMAGING IN FEMALE AND MALE MICE. THESE STUDIES REPRESENT A NUMBER OF FIRSTS IN THE AD FIELD: 1) THE FIRST TO TEST THE CONTROVERSIAL HYPOTHESIS THAT ANXIETY CAN BE A PREDICTOR OF AD IN FEMALES; 2) THE FIRST TO INVESTIGATE SEX DIFFERENCES ACROSS THE WHOLE BRAIN AS THE DISEASE PROGRESSES; 3) THE FIRST TO USE IN VIVO CA2+ IMAGING TO TAG AN INDIVIDUAL MEMORY AND ASSES NEURONAL ACTIVITY DURING BEHAVIOR IN AD MICE; AND 4) THE FIRST TO TEST THE THERAPEUTIC POTENTIAL OF TARGETING NEURAL CORRELATES OF MEMORY AND ANXIETY IN AD MICE. IN AIM 1, BEHAVIORAL DIFFERENCES WILL BE CORRELATE ANXIETY-LIKE BEHAVIOR WITH MEMORY LOSS ACROSS NUMEROUS AGES AS AD PROGRESSES. IN AIM 2, THE INDIVIDUAL NEURONS CORRESPONDING TO A MEMORY WILL BE INVESTIGATED BY UTILIZING A TRANSGENIC LINE, THE ARCCREERT2 MICE BRED WITH AN AD LINE (APP/PS1). THIS MOUSE LINE ALLOWS FOR THE INDELIBLE LABELING OF CELLS EXPRESSING THE IMMEDIATE EARLY GENE (IEG) ARC/ARG3.1 AND ALLOWS FOR A COMPARISON BETWEEN THE CELLS THAT ARE ACTIVATED DURIN