UNDERSTANDING AND REVERSING THE EFFECTS OF EARLY LIFE ADVERSITY ON MIDLIFE HEALTH: IMPROVING DAILY PSYCHOLO…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
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ASST_NON_R00AG062778_075 · REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISC… · Department of Health and Human Services
Compare Multiple AI Models with SmartSoloExplore CaptureIQ IntelligenceAssistance award details
- Assistance award identifier
- ASST_NON_R00AG062778_075
- FAIN
- R00AG062778
- Recipient
- REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $803,521
- Period
- Apr 15, 2019 – Jan 31, 2024
- Fiscal year
- 2021
- Place of performance state
- CA
- Source file
- FY2021_All_Assistance_Full_20261006.zip
Description
UNDERSTANDING AND REVERSING THE EFFECTS OF EARLY LIFE ADVERSITY ON MIDLIFE HEALTH: IMPROVING DAILY PSYCHOLOGICAL STRESS RESPONSES USING AN ECOLOGICAL MOMENTARY INTERVENTION - PROJECT SUMMARY/ABSTRACT EARLY LIFE ADVERSITY (ELA), SUCH AS CHILDHOOD MALTREATMENT, CAN LEAVE A âSCARâ INTO ADULT LIFE AND BEYOND, INCREASING RISK FOR MENTAL HEALTH PROBLEMS AND PHYSICAL DISEASES OF AGING. ELA IS ALSO LINKED WITH BIOLOGICAL INDICES THAT ARE RELIABLE PRECURSORS TO EARLY DISEASE, SUCH AS ELEVATED BLOOD PRESSURE AND C-REACTIVE PROTEIN, AND SHORTENED TELOMERE LENGTHâBIOMARKERS I WILL STUDY IN THIS PROPOSAL. IDENTIFYING THE PERSISTENT RISK PATHWAYS BY WHICH ELA WORSENS MIDLIFE HEALTH CAN INFORM INTERVENTIONS. WHILE RESEARCH ON THE BIOLOGICAL MECHANISMS HAS PROLIFERATED, OUR UNDERSTANDING OF THE PSYCHOLOGICAL MECHANISMS, WHICH CAN INFORM NON-PHARMACOLOGICAL INTERVENTIONS, HAS LAGGED BEHIND. CONGRUENT WITH THE NATIONAL INSTITUTE ON AGINGâS INITIATIVE ON THE REVERSIBILITY OF ELA, THE PROPOSED PROJECT AIMS TO 1) UNDERSTAND DAILY PSYCHOLOGICAL STRESS RESPONSES (E.G., NEGATIVE AFFECT, STRESS APPRAISALS, AND PERSEVERATIVE COGNITIONS) AS A PROMISING PSYCHOLOGICAL RISK PATHWAY, AND TO 2) DEVELOP AND 3) PILOT TEST AN INTERVENTION THAT IMPROVES MALADAPTIVE PSYCHOLOGICAL RESPONSES TO DAILY STRESSORS. THE PROPOSED INTERVENTION WILL USE DAILY MINDFULNESS-BASED PRACTICES THAT ARE INCORPORATED INTO EVERYDAY LIFE VIA MOBILE TECHNOLOGY (ECOLOGICAL MOMENTARY INTERVENTION). TO THIS END, I WILL FIRST IDENTIFY INTERVENTION TARGETS BY EXAMINING RELATIONS BETWEEN ELA, DAILY PSYCHOLOGICAL STRESS RESPONSES, AND HEALTH OUTCOMES (MENTAL/PHYSICAL SYMPTOMS; BIOMARKERS) IN TWO EXISTING MIDLIFE STUDIES WITH PROSPECTIVE AND RETROSPECTIVE ASSESSMENTS OF ELA. NEXT, I WILL DEVELOP AN ECOLOGICAL MOMENTARY MINDFULNESS-BASED INTERVENTION (EMMI) THAT IMPROVES MALADAPTIVE DAILY PSYCHOLOGICAL STRESS RESPONSES USING A SMALL MICRO-RANDOMIZED TRIAL (N=20). LASTLY, I WILL PILOT TEST ACCEPTABILITY, FEASIBILITY, AND ADHE