SIMULATION FRAMEWORK TO DEVELOP ANKLE EXOSKELETON GAIT ASSISTANCE FOR OLDER ADULTS - PROJECT SUMMARY / ABST…

Assistance award details

Assistance award identifier

ASST_NON_R00AG065524_075

FAIN

R00AG065524

Recipient

NORTHEASTERN UNIVERSITY

Awarding agency

Department of Health and Human Services

Funding agency

Department of Health and Human Services

Assistance listing (CFDA)

93.866

Total obligated

$779,995

Period

Apr 1, 2020 – Mar 31, 2025

Fiscal year

2022

Place of performance state

MA

Source file

FY2022_All_Assistance_Full_20261006.zip

Description

SIMULATION FRAMEWORK TO DEVELOP ANKLE EXOSKELETON GAIT ASSISTANCE FOR OLDER ADULTS - PROJECT SUMMARY / ABSTRACT THE CANDIDATE'S LONG-TERM OBJECTIVE IS TO ENABLE OPTIMAL AND CUSTOMIZED INTERVENTION TO IMPROVE MOBILITY. MO- BILITY IS AN ESSENTIAL PHYSICAL ACTIVITY FOR MAINTAINING AN ACTIVE LIFESTYLE AND FUNCTIONAL INDEPENDENCE AND IS A COMMON ISSUE FOR OLDER ADULTS, WHERE MUSCULOSKELETAL DISEASES ARE THE LEADING CAUSE OF MOBILITY LIMITATIONS. WHILE ROBOTIC ORTHOSES, OR EXOSKELETONS, PROMISE TO IMPROVE MOBILITY, THE PROGRESS IN RESEARCH IS SLOW AS EVAL- UATION ON THE OUTCOME OF GAIT ASSISTANCE CURRENTLY REQUIRES EXTENSIVE EXPERIMENTS WITH HUMAN SUBJECTS. IN THIS PROJECT, THE CANDIDATE PROPOSES TO DEVELOP A COMPUTER SIMULATION FRAMEWORK THAT CAN PREDICT THE GAIT DYNAMICS AND PERFORMANCE OF DIFFERENT ANKLE-EXOSKELETON ASSISTANCES. THE STUDY WILL DEVELOP AND EVALUATE HOW ANKLE- EXOSKELETON ASSISTANCE AFFECTS METABOLIC ENERGY CONSUMPTION, WALKING SPEED, AND PAIN DURING WALKING IN HEALTHY YOUNG AND OLDER ADULTS AS WELL AS IN OLDER ADULTS WITH KNEE OSTEOARTHRITIS. THE CANDIDATE WILL DEVELOP THE SIMULATION FRAMEWORK BASED ON A COMPUTATIONAL NEUROMECHANICAL HUMAN LOCOMOTION MODEL HE HAS PREVI- OUSLY DEVELOPED, AND COLLECT HUMAN GAIT DATA USING AN ANKLE-EXOSKELETON EMULATOR DEVELOPED IN HIS LABORATORY TO VALIDATE THE PREDICTIONS OF THE FRAMEWORK. IN ADDITION TO THE SIMULATION FRAMEWORK, THE STUDY WILL DELIVER AN- KLE-EXOSKELETON STRATEGIES THAT CAN EFFECTIVELY ASSIST HEALTHY YOUNG AND OLDER ADULTS AND THOSE WITH KNEE OSTEO- ARTHRITIS TO WALK MORE EFFICIENTLY, FAST, AND WITH LESS PAIN. DURING THE K99 PHASE, THE CANDIDATE WILL RECEIVE TRAIN- ING IN THE DEPARTMENT OF MECHANICAL ENGINEERING AT STANFORD UNIVERSITY. THE MENTORING TEAM CONSISTS OF FOUR EXPERTS WHO CAN PROVIDE TRAINING IN EXPERIMENTAL HUMAN BIOMECHANICS, COMPUTER SIMULATION OF HUMAN MOVE- MENT, MUSCULOSKELETAL DISEASES IN OLDER ADULTS, AND GERONTOLOGY. AN ADVISORY COMMITTEE WITH THREE MEMBERS WILL PROVIDE ADDITIONAL EX