EXAMINING THE ROLE OF THE NEIGHBORHOOD ENVIRONMENT ON MUSCLE FUNCTION IN OLDER ADULTS - PROJECT SUMMARY/ABS…

Assistance award details

Assistance award identifier

ASST_NON_R00AG066846_075

FAIN

R00AG066846

Recipient

REGENTS OF THE UNIVERSITY OF MICHIGAN

Awarding agency

Department of Health and Human Services

Funding agency

Department of Health and Human Services

Assistance listing (CFDA)

93.866

Total obligated

$786,481

Period

Jan 1, 2021 – Dec 31, 2025

Fiscal year

2023

Place of performance state

MI

Source file

FY2023_All_Assistance_Full_20261006.zip

Description

EXAMINING THE ROLE OF THE NEIGHBORHOOD ENVIRONMENT ON MUSCLE FUNCTION IN OLDER ADULTS - PROJECT SUMMARY/ABSTRACT POOR MUSCLE FUNCTION IS A PRESSING PUBLIC HEALTH PROBLEM: HALF OF ALL U.S. OLDER ADULTS MEET CRITERIA FOR MUSCLE WEAKNESS. POOR MUSCLE FUNCTION, DEFINED BY LOW MUSCLE STRENGTH AND POWER, IS A MAJOR RISK FACTOR FOR A HOST OF NEGATIVE HEALTH OUTCOMES, INCLUDING FUNCTIONAL LIMITATIONS, DISABILITY AND MULTIMORBIDITY. NEIGHBORHOOD CHARACTERISTICS PREDICT FUNCTIONAL LIMITATIONS, DISABILITY AND DEATH, BUT THE BIOLOGIC MECHANISMS ARE POORLY UNDERSTOOD. MUSCLE FUNCTION AND ITS UNDERLYING PHYSIOLOGY, INCLUDING MITOCHONDRIAL BIOENERGETICS, ARE A BIOLOGICALLY PROMISING, BUT UNEXPLORED MECHANISM LINKING NEIGHBORHOODS AND DISABILITY. WHILE PREVIOUS RESEARCH HAS EXAMINED NEIGHBORHOOD EFFECTS ON DISABILITY, ALMOST NO PRIOR WORK HAS EXPLORED NEIGHBORHOOD EFFECTS ON MUSCLE FUNCTION AND NO RESEARCH HAS EVALUATED CONNECTIONS WITH SKELETAL MUSCLE MITOCHONDRIA. NEIGHBORHOOD FACTORS REPRESENT AN UNTAPPED OPPORTUNITY IN MUSCULOSKELETAL HEALTH RESEARCH DIRECTLY ALIGNED WITH NIA'S STRATEGIC GOALS TO “ASSESS THE INTERPLAY AMONG ENVIRONMENTAL, SOCIOCULTURAL, BEHAVIORAL, AND BIOLOGICAL DETERMINANTS TO UNDERSTAND AND PREVENT DISEASE” WHILE “EXPLORING THE RELATIONSHIP AMONG MITOCHONDRIAL BIOGENESIS AND MUSCULOSKELETAL FUNCTION”. UNDERSTANDING HOW NEIGHBORHOOD CHARACTERISTICS GET `UNDER THE SKIN' AND CONTRIBUTE TO POOR MUSCLE FUNCTION, REDUCED PHYSICAL ACTIVITY, AND ALTER MITOCHONDRIAL BIOENERGETICS WILL ENHANCE OUR UNDERSTANDING OF WHAT SOCIAL AND BIOLOGIC RISK FACTORS MATTER MOST FOR MUSCLE FUNCTION AND COULD BE TARGETS FOR INTERVENTIONS. THIS STUDY PROPOSAL LEVERAGES DATA FROM TWO WELL-CHARACTERIZED DATASETS, THE HEALTH AND RETIREMENT STUDY (HRS) AND THE STUDY OF MUSCLE MOBILITY AND AGING (SOMMA) TO IDENTIFY WHICH FEATURES OF THE NEIGHBORHOOD ENVIRONMENT ARE RELATED TO MUSCLE FUNCTION, PHYSICAL ACTIVITY AND MITOCHONDRIAL HEALTH IN OLDER ADULTS. THIS PROPOSAL SEEKS TO: (1) ASS