PRECLINICAL MARKERS OF ALZHEIMER'S DISEASE USING PSYCHOLINGUISTIC SEMANTIC MEASURES - PROJECT ABSTRACT THE…
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ASST_NON_R00AG066934_075 · REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISC… · Department of Health and Human Services
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- Assistance award identifier
- ASST_NON_R00AG066934_075
- FAIN
- R00AG066934
- Recipient
- REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $1,197,825
- Period
- Jun 1, 2022 – May 31, 2025
- Fiscal year
- 2022
- Place of performance state
- CA
- Source file
- FY2022_All_Assistance_Full_20261006.zip
Description
PRECLINICAL MARKERS OF ALZHEIMER'S DISEASE USING PSYCHOLINGUISTIC SEMANTIC MEASURES - PROJECT ABSTRACT THE CLINICAL DIAGNOSIS OF ALZHEIMER'S DISEASE (AD) IS BASED ON THE CORE CRITERION OF MEMORY IMPAIRMENT, BUT BIOMARKER-DETECTABLE PATHOPHYSIOLOGICAL CHANGES START DECADES BEFORE CLINICAL SYMPTOMS. THIS PRECLINICAL PHASE, IN WHICH SOMEONE HAS THE NEUROPATHOLOGY OF AD BUT DOES NOT YET SHOW CLINICAL SYMPTOMS, IS CRUCIAL FOR POTENTIAL INTERVENTION AND TIMELY DIAGNOSIS FOR PATIENT AND CAREGIVER. THE PRECLINICAL PHASE IS CURRENTLY ONLY DETECTABLE WITH EXPENSIVE OR INVASIVE BIOMARKERS. BECAUSE CURRENT COGNITIVE MEASURES ARE NOT SENSITIVE TO THE PRECLINICAL PHASE OF AD AND HAVE LOW SPECIFICITY AND LARGE VARIATION WITH REGARD TO INDIVIDUALS' EDUCATIONAL AND CULTURAL EXPOSURE, THERE IS A CRITICAL NEED TO DEVELOP SENSITIVE, LOW-COST, AND HIGH-ACCESS COGNITIVE MARKERS FOR EARLY DETECTION IN DIVERSE OLDER ADULTS. THE PRIMARY GOAL OF THIS PROJECT IS TO INVESTIGATE IF NOVEL PSYCHOLINGUISTIC METRICS OF EXISTING COGNITIVE TEST DATA CAN ACCURATELY IDENTIFY PEOPLE IN THE EARLIEST STAGES OF AD. THE SEMANTIC FLUENCY TASKâNAMING AS MANY ANIMALS IN ONE MINUTEâTESTS SEMANTIC MEMORY, ONE OF THE FIRST COGNITIVE DOMAINS TO BECOME IMPAIRED IN AD. TRADITIONALLY, SEMANTIC FLUENCY IS SCORED BY THE TOTAL NUMBER OF ITEMS. HOWEVER, THERE IS A WEALTH OF INFORMATION AT THE ITEM-LEVEL OF THIS TASK, BECAUSE WORDS ARE ORGANIZED IN A SEMANTIC NETWORK THAT BECOMES VULNERABLE DURING AD, SPECIFICALLY FOR WORDS THAT ARE POORLY CONNECTED AND NOT OFTEN USED. THESE TRAITS OF WORDS IN THE SEMANTIC NETWORK CAN BE CAPTURED WITH NOVEL PSYCHOLINGUISTIC METRICS, SUCH AS LEXICAL FREQUENCY, E.G., `DOG' IS A HIGH-FREQUENT WORD IN OUR LANGUAGE, AS OPPOSED TO `IGUANA.' NINE NOVEL ITEM-LEVEL PSYCHOLINGUISTIC METRICS OF SEMANTIC FLUENCY HAVE BEEN SELECTED TO: INVESTIGATE HOW AD IMAGING BIOMARKERS IN NONDEMENTED ADULTS RELATE TO PSYCHOLINGUISTIC MEASURES (AIM 1, K99); ESTIMATE THE TEMPORALITY OF SEMANTIC IMPAIRMENT ACROSS