REAL-TIME MANIPULATIONS TO UNDERSTAND AND IMPROVE MEMORY PROCESSES - PROJECT SUMMARY/ABSTRACT THE HIPPOCAMP…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
Assistance award details
- Assistance award identifier
- ASST_NON_R00AG068425_075
- FAIN
- R00AG068425
- Recipient
- UNIVERSITY OF WASHINGTON
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $754,447
- Period
- May 15, 2021 – Jan 31, 2026
- Fiscal year
- 2023
- Place of performance state
- WA
- Source file
- FY2023_All_Assistance_Full_20261006.zip
Description
REAL-TIME MANIPULATIONS TO UNDERSTAND AND IMPROVE MEMORY PROCESSES - PROJECT SUMMARY/ABSTRACT THE HIPPOCAMPUS IS CRITICAL FOR CAPTURING RICH, MULTIMODAL REPRESENTATIONS OF EXPERIENCE AND FACILITATING THE LONG-TERM STORAGE AND LATER RECALL OF THESE EXPERIENCES. DURING SLEEP AND PAUSES IN BEHAVIOR, THE HIPPOCAMPUS CAN âREPLAYâ PRIOR EXPERIENCE â REACTIVATING THE NEURAL ENSEMBLE CORRESPONDING TO THE ORIGINAL EXPERIENCE IN A TIME-COMPRESSED MANNER. DURING SLEEP, SUCH REPLAY IS THOUGHT TO UNDERLIE MEMORY CONSOLIDATION, WHILE DURING BEHAVIOR, REPLAY IS THOUGHT TO ADDITIONALLY SERVE A MORE PROSPECTIVE ROLE: CONTRIBUTING TO PLANNING OR DELIBERATION BY RETRIEVING STORED MEMORIES IN ORDER TO INFORM UPCOMING DECISIONS. HOWEVER, THE CONTENT OF REPLAY NEITHER SOLELY REFLECTS RECENT EXPERIENCE NOR RELIABLY PREDICTS FUTURE BEHAVIOR, LEAVING IT UNCLEAR HOW EXACTLY THE REPRESENTATIONS OF EXPERIENCE THAT ARE REPLAYED RELATE TO UPCOMING CHOICES. UNDERSTANDING THE RELATIONSHIP BETWEEN REPLAY AND BEHAVIOR IS PARTICULARLY CRITICAL BECAUSE ABNORMALITIES IN REPLAY AND SHARP WAVE RIPPLES (SWRS; THE NETWORK ACTIVITY SIGNATURE OF REPLAY) HAVE BEEN OBSERVED CONCURRENT WITH IMPAIRED MEMORY-DEPENDENT BEHAVIOR IN AGING AND DISEASES OF AGING. ESTABLISHING HOW REPLAY CONTENT CHANGES WITH AGING, AND WHETHER THESE CHANGES CAUSE DEFICITS IN MEMORY-GUIDED BEHAVIOR, HAS THE POTENTIAL TO GENERATE NEW THERAPEUTIC STRATEGIES TO PREVENT OR REVERSE MEMORY IMPAIRMENT. IN ORDER TO DEFINE HOW REPLAY CONTRIBUTES TO MEMORY-GUIDED DECISION-MAKING IN NORMAL COGNITION AND IN THE CONTEXT OF AGE-RELATED MEMORY IMPAIRMENT, WE HAVE DEVELOPED A NEUROFEEDBACK-BASED OPERANT CONDITIONING PARADIGM THAT TARGETS SWRS. THIS PARADIGM PROVIDES RAPID FEEDBACK CONTINGENT UPON REAL-TIME DETECTION OF SWRS AT A SPECIFIC POINT DURING EACH TRIAL OF A SPATIAL MEMORY TASK, AND RESULTS IN SUBSTANTIALLY INCREASED OCCURRENCE OF SWRS IN A TRIAL PHASE- SPECIFIC MANNER. CONSEQUENTLY, SUBJECTS EXPERIENCE MORE REPLAY AT THE REQUIRED TRIAL P