EPIDEMIOLOGIC, IMAGING AND PATHOLOGICAL STUDIES OF THE ROLE OF BLOOD PRESSURE VARIABILITY IN DEMENTIA ETIOL…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
Assistance award details
- Assistance award identifier
- ASST_NON_R00AG071742_075
- FAIN
- R00AG071742
- Recipient
- PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $779,502
- Period
- Sep 1, 2021 – Feb 28, 2026
- Fiscal year
- 2023
- Place of performance state
- MA
- Source file
- FY2023_All_Assistance_Full_20261006.zip
Description
EPIDEMIOLOGIC, IMAGING AND PATHOLOGICAL STUDIES OF THE ROLE OF BLOOD PRESSURE VARIABILITY IN DEMENTIA ETIOLOGY - APPLICATION NUMBER: 1 K99 AG071742-01 PI: MA, YUAN MODIFIED PROJECT SUMMARY/ABSTRACT SECTION EPIDEMIOLOGIC, IMAGING AND PATHOLOGICAL STUDIES OF THE ROLE OF BLOOD PRESSURE VARIABILITY IN THE ETIOLOGY OF ALZHEIMER'S DISEASE AND RELATED DEMENTIAS PROJECT SUMMARY THE ETIOLOGY OF ALZHEIMER'S DISEASE AND RELATED DEMENTIAS (ADRD; HEREINAFTER, USED INTERCHANGEABLY WITH DEMENTIA) IN OLDER ADULTS IS MULTIFACTORIAL, AND VASCULAR RISK FACTORS, ESPECIALLY HYPERTENSION, ARE MAJOR MODIFIABLE CONTRIBUTORS. HOWEVER, THE RELATIONSHIP BETWEEN BLOOD PRESSURE (BP) AND DEMENTIA IS FAR FROM CLEAR. INCREASED BP VARIABILITY OVER DIFFERENT PERIODS HAS BEEN LINKED TO CARDIOVASCULAR DISEASE AND MORTALITY RISK INDEPENDENT OF STATIC BP LEVELS. EMERGING EVIDENCE HAS ALSO SUGGESTED BP VARIABILITY AS A NOVEL RISK FACTOR FOR ALZHEIMER'S DISEASE AND RELATED DEMENTIAS. BUT THE CLINICAL TRANSLATION OF BP VARIABILITY FOR THE RISK STRATIFICATION AND PREVENTION OF ALZHEIMER'S DISEASE AND RELATED DEMENTIAS HAS BEEN HAMPERED BY THE LACK OF STANDARDS FOR ASSESSING BP VARIABILITY AND THE LACK OF KNOWLEDGE ON THE UNDERLYING MECHANISMS. THE GOALS OF THIS PROJECT ARE TO 1) COMPREHENSIVELY QUANTIFY THE EPIDEMIOLOGICAL RELATIONSHIP BETWEEN BP VARIABILITY AND ALZHEIMER'S DISEASE AND RELATED DEMENTIAS AND 2) IDENTIFY THE CAUSAL PATHWAYS LINKING BP VARIABILITY TO ALZHEIMER'S DISEASE AND RELATED DEMENTIAS. TO ACCOMPLISH THESE, THE DATA FROM 6 PROSPECTIVE COHORT STUDIES ACROSS THE US AND EUROPE WILL BE ANALYZED: THE FRAMINGHAM HEART STUDY, THE ROTTERDAM STUDY, THE THREE-CITY STUDY, THE ATHEROSCLEROSIS RISK IN COMMUNITIES STUDY, AND THE RUSH RELIGIOUS ORDERS STUDY AND MEMORY AND AGING PROJECT. IN AIM 1, THE RELATIONSHIP BETWEEN 3 TYPES OF BP VARIABILITY (VISIT-TO-VISIT VARIABILITY, BEAT-TO-BEAT VARIABILITY, AND POSTURAL VARIABILITY) AND THE RISK OF ALZHEIMER'S DISEASE AND RELATED DEMENTIAS WILL BE QUANTIFIED