REGIONAL TAU DEPOSITION AND DIGITAL ASSESSMENT OF COGNITION IN PRECLINICAL AD AND MCI - PROJECT SUMMARY THE…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
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ASST_NON_R00AG071837_075 · UNIVERSITY OF CALIFORNIA, DAVIS · Department of Health and Human Services
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- Assistance award identifier
- ASST_NON_R00AG071837_075
- FAIN
- R00AG071837
- Recipient
- UNIVERSITY OF CALIFORNIA, DAVIS
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $605,719
- Period
- Sep 1, 2022 – Aug 31, 2028
- Fiscal year
- 2025
- Place of performance state
- CA
- Source file
- FY2025_All_Assistance_Full_20261006.zip
Description
REGIONAL TAU DEPOSITION AND DIGITAL ASSESSMENT OF COGNITION IN PRECLINICAL AD AND MCI - PROJECT SUMMARY THE APPLICANT SEEKS THIS ADMINISTRATIVE SUPPLEMENT IN RELATION TO HER R00 AWARD, WHICH EXAMINES THE ASSOCIATION BETWEEN REGIONAL TAU DEPOSITION AND DOMAIN-SPECIFIC COGNITIVE DECLINE GIVEN THAT PATHOLOGICAL AND CLINICAL EVIDENCE OF ALZHEIMERâS DISEASE CONVERGES TO SUGGEST THAT BOTH EPISODIC AND SEMANTIC MEMORY ARE VULNERABLE YEARS BEFORE THE ONSET OF DEMENTIA. DURING THE K99 PHASE, SHE EXAMINED HOW REGIONAL TAU DEPOSITION RELATES TO EPISODIC AND SEMANTIC MEMORY DECLINE IN TWO LARGE COHORTS CONSISTING OF AÎ- CLINICALLY NORMAL (CN), AÎ+ CN, AND AÎ+ MILD COGNITIVE IMPAIRMENT (MCI) INDIVIDUALS. EPISODIC AND SEMANTIC MEMORY WERE MEASURED BY TRADITIONAL NEUROPSYCHOLOGICAL TEST SCORES AS WELL AS INNOVATIVE SPOKEN LANGUAGE FEATURES OF COGNITION EXTRACTED FROM RECORDINGS OF IN-PERSON NEUROPSYCHOLOGICAL ASSESSMENTS. THE APPLICANT RECEIVED TRAINING IN THREE AREAS CRITICAL TO HER INDEPENDENCE: (1) LONGITUDINAL STUDY DESIGN AND ANALYSIS IN ALZHEIMERâS DISEASE, (2) AMYLOID AND TAU PET IMAGING, AND (3) SPOKEN LANGUAGE FEATURES OF COGNITION. SHE ALSO RECEIVED GUIDANCE FROM HER EXPERT MENTORSHIP TEAM WHO HAS AN ESTABLISHED RECORD OF MENTORING JUNIOR SCHOLARS TO FULL INDEPENDENCE, AND OBTAINED COMPREHENSIVE TRAINING THROUGH A DETAILED TRAINING PLAN. HER RESEARCH AIM, IN COMBINATION WITH THE TRAINING AND MENTORSHIP SHE RECEIVED, PREPARED HER FOR INDEPENDENCE BY THE R00 PHASE AS EVIDENCED BY HER TRANSITION TO AN TENURE-TRACK ASSISTANT PROFESSOR POSITION IN THE DEPARTMENTS OF RADIOLOGY AND NEUROLOGY AT UC DAVIS. DURING THE R00 PHASE, SHE WILL EXAMINE THE RELATION BETWEEN REGIONAL TAU DEPOSITION AND DOMAIN-SPECIFIC COGNITIVE DECLINE ASSESSED FREQUENTLY THROUGH SMARTPHONES, AN INCREASINGLY UBIQUITOUS PLATFORM. SPECIFICALLY, SHE WILL ADMINISTER VERBALLY BASED MOBILE COGNITIVE TESTS AND ASSESSMENTS OF MOOD EVERY 3 MONTHS FOR 1 YEAR TO AÎ- CN, AÎ+ CN, AND AÎ+ MCI INDIVIDUALS WITH