GENETIC AND NEUROPATHOLOGIC UNDERPINNINGS OF SEX DIFFERENCES IN LEWY BODY DEMENTIAS - PROJECT SUMMARY SEX D…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
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ASST_NON_R00AG073453_075 · THE REGENTS OF THE UNIVERSITY OF COLORADO · Department of Health and Human Services
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- Assistance award identifier
- ASST_NON_R00AG073453_075
- FAIN
- R00AG073453
- Recipient
- THE REGENTS OF THE UNIVERSITY OF COLORADO
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $725,178
- Period
- Jul 1, 2022 – Jul 31, 2027
- Fiscal year
- 2024
- Place of performance state
- CO
- Source file
- FY2024_All_Assistance_Full_20261006.zip
Description
GENETIC AND NEUROPATHOLOGIC UNDERPINNINGS OF SEX DIFFERENCES IN LEWY BODY DEMENTIAS - PROJECT SUMMARY SEX DIFFERENCES ARE COMMONLY REPORTED IN LEWY BODY DEMENTIA, ALTHOUGH THE REASONS ARE UNKNOWN. PHENOTYPIC DIFFERENCES CAN BE DESCRIBED BY DIFFERENCES IN THE PATHOLOGY AND CAN BE ASSOCIATED WITH DIFFERENCES IN GENETIC RISK LOCI. WE HYPOTHESIZE THAT ALZHEIMER'S DISEASE-RELATED GENETIC RISK FACTORS WILL BE ASSOCIATED WITH HIGHER DEMENTIA RISK IN WOMEN WITH LEWY BODY DEMENTIA, GIVEN THE HIGHER LIKELIHOOD OF ALZHEIMER'S CO-PATHOLOGY IN WOMEN. HOWEVER, EVEN FOR WOMEN WITH PURE LEWY BODY PATHOLOGY, ALZHEIMER'S PHENOTYPE IS MORE COMMON THAN LEWY BODY DEMENTIA PHENOTYPE, INDICATING SEX DIFFERENCES FOR CLINICOPATHOLOGIC CORRELATIONS. THIS MAY BE DUE TO DIFFERENCES IN REGIONAL PATHOLOGY BURDEN FOR MEN AND WOMEN. SPECIFIC REGIONAL LEWY BODY AND ALZHEIMER'S PATHOLOGY BURDEN HAVE BEEN ASSOCIATED WITH DIFFERENT SYMPTOMS; AND WE HYPOTHESIZE THAT MEN WILL HAVE MORE NEOCORTICAL LEWY BODY BURDEN AND WOMEN WILL HAVE MORE PATHOLOGY BURDEN IN THE MEDIAL TEMPORAL LOBE GIVEN THE MORE COMMON ALZHEIMER'S PHENOTYPE IN WOMEN. AS ALZHEIMER'S DISEASE IS THE MOST COMMON MISDIAGNOSIS FOR PATIENTS WITH LEWY BODY DEMENTIA, WE WILL ALSO DEVELOP SEX-SPECIFIC MODELS WITH CLINICAL AND GENETIC VARIABLES TO CLINICALLY DIFFERENTIATE LEWY BODY AND ALZHEIMER'S PATHOLOGY. THESE FINDINGS WILL IMPROVE OUR UNDERSTANDING OF THE ETIOPATHOGENESIS OF LEWY BODY DEMENTIA, ASSIST WITH PATIENT SELECTION FOR FUTURE CLINICAL TRIALS IN BOTH LEWY BODY DEMENTIA AND ALZHEIMER'S DISEASE, AND PROVIDE TARGETS FOR PRECISION MEDICINE IN THESE NEURODEGENERATIVE DEMENTIAS. THE CANDIDATE IS AN ASSISTANT PROJECT SCIENTIST (A MENTORED POSITION) AT THE UNIVERSITY OF CALIFORNIA SAN DIEGO. SHE HAS AN MD AND A PHD WITH PRIOR TRAINING IN NEURODEGENERATIVE DISORDERS, NEUROPSYCHOLOGY, AND NEUROIMAGING. SHE HAS A HISTORY OF PRODUCTIVITY, HAVING CONDUCTED TRANSLATIONAL AND CLINICAL RESEARCH IN MOVEMENT DISORDERS, RECENTLY FOCUSING ON SEX DIFFER