LIFECOURSE COMMUNITY CONTEXTS AND HEALTH BEHAVIORS AS DRIVERS OF DISPARITIES IN RISK OF ALZHEIMER'S DISEASE…

Assistance award details

Assistance award identifier

ASST_NON_R00AG073457_075

FAIN

R00AG073457

Recipient

UNIVERSITY OF MONTANA

Awarding agency

Department of Health and Human Services

Funding agency

Department of Health and Human Services

Assistance listing (CFDA)

93.866

Total obligated

$741,836

Period

Sep 1, 2022 – Jun 30, 2025

Fiscal year

2022

Place of performance state

MT

Source file

FY2022_All_Assistance_Full_20261006.zip

Description

LIFECOURSE COMMUNITY CONTEXTS AND HEALTH BEHAVIORS AS DRIVERS OF DISPARITIES IN RISK OF ALZHEIMER'S DISEASE AND RELATED DEMENTIAS - PROJECT SUMMARY/ABSTRACT ALZHEIMER'S DISEASE AND RELATED DEMENTIAS (ADRD) ARE A PRESSING PUBLIC HEALTH ISSUE WITH SUBSTANTIAL DISPARITIES. ADRD CAN ONLY BE ADDRESSED BY MINIMIZING THE IMPACT OF MODIFIABLE RISK FACTORS – ESPECIALLY HEALTH BEHAVIORS. HOWEVER, EVIDENCE SUGGESTS THAT HEALTH BEHAVIORS ARE SHAPED BY THE COMMUNITY CONTEXTS (I.E. BUILT AND SOCIAL ENVIRONMENTS) IN WHICH WE LIVE, WORK, PLAY, AND AGE. FAILURE TO UNDERSTAND AND ACCOUNT FOR COMMUNITY- LEVEL CONTEXTUAL FACTORS IN ADRD RISK REDUCTION MAY MINIMIZE THE IMPACT OF PUBLIC HEALTH MEASURES TO REDUCE THE RISK OF ADRD AND WORSEN HEALTH DISPARITIES. INVESTIGATING PATHWAYS THAT CONNECT COMMUNITY CONTEXTUAL FACTORS, HEALTH BEHAVIOR ENGAGEMENT, AND DISPARITIES IN ADRD RISK IS AN UNTAPPED OPPORTUNITY TO ADVANCE THE SCIENCE ADRD RISK REDUCTION, AND IS ALIGNED WITH NIA'S STRATEGIC GOALS BY “ILLUMINAT(ING) THE PATHWAYS BY WHICH SOCIAL, PSYCHOLOGICAL, ECONOMIC, AND BEHAVIORAL FACTORS AFFECT HEALTH,” AND “UNDERSTAND(ING) ENVIRONMENTAL, SOCIAL, CULTURAL, BEHAVIORAL, AND BIOLOGICAL FACTORS THAT CREATE AND SUSTAIN HEALTH DISPARITIES.” THIS STUDY LEVERAGES DATA FROM TWO INNOVATIVE PROJECTS FUNDED BY THE NIH (KAISER HEALTHY AGING AND DIVERSE LIFE EXPERIENCES (KHANDLE); NEIGHBORHOOD ATLAS) AND THE POLICYMAP DATABASE TO IDENTIFY WHEN AND HOW COMMUNITY CONTEXTUAL FACTORS SHAPE HEALTH BEHAVIORS AND ADRD RISK AND DISPARITIES. THIS PROJECT WILL LINK KHANDLE PARTICIPANTS' RESIDENTIAL HISTORIES FROM BIRTH TO LATE-LIFE WITH THE VALIDATED AREA DEPRIVATION INDICES AVAILABLE VIA THE NEIGHBORHOOD ATLAST FROM 1910 TO PRESENT, AND GEOCODED MEASURES OF THE BUILT ENVIRONMENT AVAILABLE VIA POLICYMAP. THIS PROPOSAL SEEKS TO DEFINE: 1) HOW THE TIMING OR DURATION OF EXPOSURE TO COMMUNITY CONTEXTS IS ASSOCIATED WITH LATE-LIFE COGNITIVE/BRAIN HEALTH; 2) IF INDIVIDUAL HEALTH BEHAVIORS MEDIATE RELATIONSHIP