ROLE OF RAB10 IN ALZHEIMER'S DISEASE - 1 PROJECT SUMMARY: âROLE OF RAB10 IN ALZHEIMERâS DISEASE, K99/R0…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
Assistance award details
- Assistance award identifier
- ASST_NON_R00AG075179_075
- FAIN
- R00AG075179
- Recipient
- UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $757,074
- Period
- Mar 15, 2022 – Dec 31, 2026
- Fiscal year
- 2024
- Place of performance state
- AL
- Source file
- FY2024_All_Assistance_Full_20261006.zip
Description
ROLE OF RAB10 IN ALZHEIMER'S DISEASE - 1 PROJECT SUMMARY: âROLE OF RAB10 IN ALZHEIMERâS DISEASE, K99/R00â 2 CANDIDATE: MY LONG-TERM CAREER GOALS CENTER ON THE ESTABLISHMENT OF A LEADING RESEARCH LABORATORY IN 3 ACADEMIA FOCUSED ON DEFINING KEY MOLECULAR MECHANISMS UNDERLYING NEURODEGENERATION AND ALZHEIMERâS 4 DISEASE (AD). SPECIFICALLY, MY RECENT RESEARCH INTERESTS HAVE NARROWED TO ASK HOW KEY REGULATORS OF ENDOCYTIC 5 TRAFFICKING PATHWAYS, PARTICULARLY RAB GTPASES AND THEIR MODIFIERS, CONTRIBUTE TO NEUROINFLAMMATION ASSOCIATED 6 WITH AD. I AM A BIOCHEMIST WITH TRAINING IN BIOPHYSICS AND CELL BIOLOGY, WITH THE INCLUDED PROPOSAL FOR ADDITIONAL 7 TRAINING IN MOUSE MODELS OF DISEASE. THESE TRAINING EXPERIENCES WILL FACILITATE FUTURE INVESTIGATIONS IN MOLECULAR 8 MECHANISMS UNDERLYING ENDOCYTIC DYSFUNCTION THAT MANIFEST IN DISEASE RELEVANT PHENOTYPES. 9 TRAINING: HERE I PROPOSE A SERIES OF TRAINING THAT INCLUDE A TRANSLATIONAL IN VIVO EXPERIMENT IN MOUSE MODELS 10 COUPLED WITH FORMAL COURSEWORK TO ACCELERATE MY TRAJECTORY TOWARDS INDEPENDENCE IN THE R00 PHASE. THESE 11 TRAINING EXPERIENCES WILL BE FACILITATED THROUGH MENTORSHIP FROM DR. ANDREW WEST, IN ADDITION TO A TRANSITION 12 ADVISORY COMMITTEE AT DUKE UNIVERSITY COMPOSED OF DR. PATRICK SULLIVAN, AN EXPERT IN MOUSE AD MODELS, DR. 13 CAROL COLTON, AN EXPERT IN MICROGLIA FUNCTION IN AD MODELS, AND DR. ROBERT LEFKOWITZ, A NOBEL-LAUREATE EXPERT 14 IN BIOCHEMISTRY AND CELL BIOLOGY. FORMAL COURSE WORK THAT IS PLANNED WILL FURTHER ENHANCE TRAINING ON IN VIVO 15 STUDY APPROACHES, GRANT WRITING, MENTORING SKILLS, LAB MANAGEMENT AND RESPONSIBLE CONDUCT IN RESEARCH. 16 RESEARCH: RECENTLY, A SINGLE NUCLEOTIDE POLYMORPHISM IN THE RAB10 3âUTR RS142787485 HAS BEEN LINKED WITH 17 STRONG RESILIENCY TO AD SUSCEPTIBILITY. TRANSCRIPTOMIC ANALYSIS REVEALS RAB10 MRNA AS HIGHER IN AD PATIENT 18 BRAINS COMPARED TO HEALTHY CONTROLS. MY LATEST POST-DOCTORAL WORK DISCLOSED THAT THE RAB10 GTPASE, HIGHLY 19 EXPRESSED IN PHAGO