BIOLOGICAL AGING, THE PROTEOME AND COGNITIVE RESILIENCE AMONG ISCHEMIC STROKE SURVIVORS - TO DATE THERE IS…

Assistance award details

Assistance award identifier

ASST_NON_R00AG075196_075

FAIN

R00AG075196

Recipient

UNIVERSITY OF FLORIDA

Awarding agency

Department of Health and Human Services

Funding agency

Department of Health and Human Services

Assistance listing (CFDA)

93.866

Total obligated

$249,000

Period

Mar 15, 2023 – Dec 31, 2028

Fiscal year

2026

Place of performance state

FL

Source file

FY2026_All_Assistance_Full_20261006.zip

Description

BIOLOGICAL AGING, THE PROTEOME AND COGNITIVE RESILIENCE AMONG ISCHEMIC STROKE SURVIVORS - TO DATE THERE IS NO DISEASE-MODIFYING THERAPY FOR COGNITIVE IMPAIRMENT AND DEMENTIA. UNDERSTANDING MECHANISMS THAT STRENGTHEN COGNITIVE RESILIENCE AND DELAY VASCULAR DEMENTIA IS A COMPLIMENTARY APPROACH TO PROTECT COGNITIVE HEALTH IN AGING. SURVIVORS OF STROKE AND VASCULAR DISORDERS ARE RAPIDLY GROWING IN THE U.S. AND CAN RAPIDLY PROGRESS TO VASCULAR DEMENTIA. COGNITIVE TRAJECTORIES ASSESSED OVER LONG DURATIONS OF FOLLOW-UP, ALLOW MONITORING OF COGNITIVE RESILIENCE AND TIMING OF DEMENTIA ONSET. TAU AND BETA-AMYLOID PATHOLOGIES, INFARCTION AND STROKE-RELATED FACTORS LEAVE ~ 59% OF THE VARIANCE IN COGNITIVE TRAJECTORY UNEXPLAINED. MECHANISMS THAT ELICIT DIFFERENCES IN COGNITIVE RESILIENCE AND TIMING OF VASCULAR DEMENTIA ONSET, REMAIN UNCLEAR. BIOLOGICAL AGING IS THE DECLINE IN SYSTEM INTEGRITY WITH ADVANCING CHRONOLOGICAL AGE AND HAS BEEN ASSOCIATED WITH AGE-RELATED DISEASES. BIOLOGICAL AGING CAN BE MEASURED BY COMPOSITE ALGORITHMS OF BIOMARKERS’ COMBINATIONS IN ROUTINE BLOOD-TESTS TO ASSESS THE UNDERLYING BODY INTEGRITY AT THE PHYSIOLOGICAL LEVEL. HOWEVER, IT REMAINS POORLY UNDERSTOOD IF BIOLOGICAL AGING EXPLAINS VARIABILITIES IN POST-STROKE COGNITIVE RESILIENCE AND TIMING OF VASCULAR DEMENTIA ONSET. AT THE MOLECULAR LEVEL, AMONG AGING BIOLOGY MECHANISMS, THE PROTEOME IS HYPOTHESIZED TO PLAY A CENTRAL ROLE IN COGNITIVE RESILIENCE AND BRAIN HEALTH. PROTEINS CONTROL CELL FUNCTIONS, CAN HELP IDENTIFY NOVEL THERAPEUTIC TARGETS AND HAVE BEEN ASSOCIATED WITH COGNITIVE TRAJECTORIES IN POSTMORTEM ASSESSMENTS. AGING-RELATED PROTEOMIC CHANGES ARE BEST DETECTED IN THE SYSTEMIC CIRCULATION. PROTEOMIC TECHNOLOGIES ALLOW MEASURING PROTEIN CHANGES IN AGING WITH HIGH LEVELS OF SPECIFICITY AND PRECISION. ESTABLISHING MOLECULAR PROTEOMIC PATHWAYS OF COGNITIVE RESILIENCE IN SURVIVORS OF STROKE AND VASCULAR DISORDERS, IS A CRITICAL STEP TO TRANSLATE BIOMARKER DISCOVERIES TO DEMENTIA TREATMENT AND