INVESTIGATING CEREBROVASCULAR REGULATION DURING EXERCISE AS A FACTOR INFLUENCING CORTICAL RESOURCE ENGAGEME…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
Assistance award details
- Assistance award identifier
- ASST_NON_R00AG075255_075
- FAIN
- R00AG075255
- Recipient
- REGENTS OF THE UNIVERSITY OF MINNESOTA
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $832,282
- Period
- Mar 15, 2024 – Feb 28, 2027
- Fiscal year
- 2024
- Place of performance state
- MN
- Source file
- FY2024_All_Assistance_Full_20261006.zip
Description
INVESTIGATING CEREBROVASCULAR REGULATION DURING EXERCISE AS A FACTOR INFLUENCING CORTICAL RESOURCE ENGAGEMENT FOR BALANCE CONTROL WITH AGING - PROJECT SUMMARY/ABSTRACT DURING THE AGING PROCESS THERE IS A LOSS OF AUTOMATICITY IN BALANCE AND MOBILITY, WHERE THE ENGAGEMENT OF CORTICAL RESOURCES FOR BALANCE CONTROL MAY INTERFERE WITH OLDER ADULTSâ ABILITY TO PERFORM COGNITIVE AND BALANCE BEHAVIORS SIMULTANEOUSLY. OVER THE COURSE OF NORMAL AGING, THERE IS A DECLINE IN CEREBRAL BLOOD FLOW THAT IS LINKED TO IMPAIRED COGNITIVE FUNCTION IN OLDER ADULTS. HOWEVER, IT REMAINS UNKNOWN WHETHER AGE-RELATED DECLINES IN CEREBROVASCULAR AND NERVOUS SYSTEM FUNCTION MAY INTERACT TO MANIFEST AS COGNITIVE INTERFERENCE IN BALANCE CONTROL THAT PRECIPITATE FALLS AND CLINICAL DEMENTIA. FURTHER, OLDER ADULTS WHO CARRY THE APOLIPOPROTEIN E4 (APOE4) ALLELE, THE GREATEST KNOWN GENETIC RISK FACTOR FOR ALZHEIMERâS DISEASE, SHOW GREATER CEREBROVASCULAR DYSFUNCTION COMPARED TO AGE-MATCHED NONCARRIERS, AND DISPLAY WORSE BALANCE PERFORMANCE UNDER COGNITIVE LOADING CONDITIONS, SUPPORTING THE POTENTIAL EFFECT OF INDIVIDUAL GENOTYPE ON THE LINK BETWEEN CEREBROVASCULAR HEALTH AND BALANCE CONTROL WITH AGING. USING ELECTROENCEPHALOGRAPHY (EEG) TO MEASURE DYNAMIC CORTICAL ACTIVITY DURING STANDING BALANCE REACTIONS, THE CANDIDATEâS RECENT FELLOWSHIP FINDINGS PROVIDE AN INDIVIDUALIZED FRAMEWORK OF CORTICAL ENGAGEMENT STRATEGIES FOR BALANCE CONTROL IN OLDER ADULTS THAT IS ASSOCIATED WITH DISTINCT ASPECTS OF BALANCE BEHAVIOR AND FALL RISK, INCLUDING COGNITIVE INTERFERENCE IN BALANCE PERFORMANCE. CURRENTLY, A MAJOR SCIENTIFIC BARRIER TO THE CLINICAL TRANSLATION OF THIS RESEARCH IS THE LACK OF UNDERSTANDING OF THE FACTORS THAT INFLUENCE INDIVIDUAL-SPECIFIC CORTICAL STRATEGIES FOR BALANCE CONTROL WITH AGING. EMERGING EVIDENCE SUGGESTS COGNITIVE IMPAIRMENT WITH AGING MAY BE CAUSED BY DYSFUNCTIONAL CEREBRAL BLOOD FLOW, SPECIFICALLY CHARACTERIZED BY IMPAIRED CEREBROVASCULAR REGULATION UNDER CONDITIONS OF PHYSIOL