EFFECTS OF LIFECOURSE TRAUMATIC STRESS ON LATE-LIFE COGNITIVE DECLINE, DEMENTIA, AND NEUROIMAGING BIOMARKER…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
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ASST_NON_R00AG075317_075 · UNIVERSITY OF SOUTHERN CALIFORNIA · Department of Health and Human Services
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- Assistance award identifier
- ASST_NON_R00AG075317_075
- FAIN
- R00AG075317
- Recipient
- UNIVERSITY OF SOUTHERN CALIFORNIA
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $741,919
- Period
- Aug 4, 2022 – May 31, 2027
- Fiscal year
- 2024
- Place of performance state
- CA
- Source file
- FY2024_All_Assistance_Full_20261006.zip
Description
EFFECTS OF LIFECOURSE TRAUMATIC STRESS ON LATE-LIFE COGNITIVE DECLINE, DEMENTIA, AND NEUROIMAGING BIOMARKERS - PROJECT SUMMARY/ABSTRACT UP TO HALF OF ALZHEIMERâS DISEASE AND ALZHEIMERâS DISEASE-RELATED DEMENTIAS (AD/ADRD) CASES ARE DUE TO POTENTIALLY MODIFIABLE EXPOSURES, INCLUDING PSYCHOSOCIAL FACTORS. EXPOSURE TO TRAUMATIC EVENTS OVER THE LIFECOURSE IS PERVASIVE, PARTICULARLY IN GROUPS THAT EXPERIENCE DISPROPORTIONATELY HIGH BURDEN OF AD/ADRD. STRESS SENSITIZATION MODELS SUGGEST THAT TRAUMA EXPOSURE, ESPECIALLY IN EARLY LIFE, CAN RESULT IN BRAIN CHANGES AND INCREASE VULNERABILITY TO PSYCHOPATHOLOGY. HOWEVER, STRESS SENSITIZATION MODELS HAVE NOT BEEN EXTENDED TO LATE- LIFE NEUROLOGICAL OUTCOMES AND VERY LITTLE RESEARCH EXISTS ON EFFECTS OF LIFECOURSE TRAUMATIC STRESS EXPOSURE ON AD/ADRD RISK. THE SCIENTIFIC OBJECTIVE OF THIS RESEARCH PLAN IS TO UNDERSTAND EFFECTS OF TRAUMATIC STRESS ON COGNITION AND NEUROIMAGING IN LATE LIFE AND TO IDENTIFY FACTORS THAT MODIFY THESE EFFECTS, INCLUDING LATE-LIFE CONTRIBUTORS TO RESILIENCE. USING STATE-OF-THE ART STATISTICAL METHODS, THE RESEARCH WILL: (1) ESTIMATE THE EFFECT OF TRAUMATIC STRESS OVER THE LIFECOURSE ON LATE-LIFE COGNITIVE DECLINE, DEMENTIA, AND NEUROIMAGING BIOMARKERS OF AD/ADRD, (2) IDENTIFY INDIVIDUAL CHARACTERISTICS AND EARLY-LIFE FACTORS (E.G. SEX/GENDER, RACE/ETHNICITY, EDUCATION) THAT MODIFY THE IMPACT OF LIFECOURSE TRAUMATIC STRESS ON LATE-LIFE COGNITIVE DECLINE AND DEMENTIA, (3) TEST THE STRESS SENSITIZATION MODEL TO DETERMINE IF CHILDHOOD TRAUMA AND ADVERSITY MODIFIES THE EFFECT OF ADULTHOOD TRAUMATIC STRESS ON LATE-LIFE COGNITIVE DECLINE AND DEMENTIA, AND (4) IDENTIFY LATE-LIFE RESILIENCE FACTORS (E.G. SOCIAL SUPPORT/INTEGRATION, FINANCIAL SECURITY, PHYSICAL ACTIVITY) THAT MITIGATE THE IMPACT OF LIFECOURSE TRAUMATIC STRESS ON LATE-LIFE COGNITIVE DECLINE AND DEMENTIA. THE PROPOSED DATA WORK USES DATA FROM THE US NATIONALLY-REPRESENTATIVE HEALTH AND RETIREMENT STUDY (HRS) AND POOLED DATA FROM TWO NEWLY AVA