IDENTITY INFLUENCES ON PSYCHOSOCIAL TRAITS, BIOLOGIC AGE, AND CARDIOVASCULAR DISEASE DISPARITIES - PROJECT…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
Assistance award details
- Assistance award identifier
- ASST_NON_R00AG075327_075
- FAIN
- R00AG075327
- Recipient
- UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $573,091
- Period
- Aug 15, 2022 – Dec 31, 2026
- Fiscal year
- 2024
- Place of performance state
- NC
- Source file
- FY2024_All_Assistance_Full_20261006.zip
Description
IDENTITY INFLUENCES ON PSYCHOSOCIAL TRAITS, BIOLOGIC AGE, AND CARDIOVASCULAR DISEASE DISPARITIES - PROJECT SUMMARY/ABSTRACT CARDIOVASCULAR DISEASE (CVD) DISPARITIES ARE INCREASINGLY ATTRIBUTED TO THE DISTINCT SOCIAL CONDITIONS IN WHICH VARIOUS SOCIAL GROUPS AGE. SOCIOECONOMIC AND PSYCHOSOCIAL FACTORS ARE KNOWN TO CAUSE CHRONIC STRESS THAT MAY INCREASE RISK OF CVD, BUT THE MECHANISMS ARE NOT FULLY CLEAR. IT IS THEREFORE IMPORTANT TO IDENTIFY FACTORS THAT MEDIATE OR MODERATE THE EFFECTS OF SOCIAL STRESSORS ON CVD. GEROSCIENTIFIC THEORY RECONCEPTUALIZES CHRONIC DISEASE AS A PRODUCT OF SUSTAINED DYSFUNCTIONAL AGING, OFFERING ADDITIONAL AVENUES FOR UNDERSTANDING HOW THE SOCIAL ENVIRONMENT IS INTERNALIZED TO INFLUENCE HEALTH. WORK EMERGING FROM THIS LITERATURE HAS IDENTIFIED EPIGENETIC DIMENSIONS OF AGING SUCH AS DNA METHYLATION WHICH APPEAR PARTICULARLY RESPONSIVE TO PSYCHOSOCIAL STRESSORS. EPIGENETIC âCLOCKSâ, OR MEASURES OF DNA METHYLATION-BASED PREDICTORS OF CHRONOLOGICAL AGE, HEALTH, AND MORTALITY MAY SERVE AS USEFUL MARKERS THAT CAN PROVIDE IMPORTANT MISSING INFORMATION ON THE RELATIONSHIPS BETWEEN SOCIAL STRESSORS, AGING, AND CVD. FURTHERMORE, PSYCHOLOGICAL FACTORS MAY ALSO PLAY AN INTEGRAL ROLE IN THESE PATHWAYS. SELF-CONCEPT IS A DETERMINANT OF A NUMBER OF IDENTITY-BASED PSYCHOSOCIAL CHARACTERISTICS ASSOCIATED WITH BOTH EPIGENETIC CHANGES AND CVD. THESE INCLUDE DISPOSITIONAL TRAITS SUCH AS OPTIMISM AND NEGATIVE AFFECT, AS WELL AS BELIEFS ABOUT SELF-WORTH AND SUBJECTIVE SOCIAL STATUS. IMPORTANTLY, THESE FACTORS ARE ALSO KNOWN TO INFLUENCE THE WAY INDIVIDUALS PERCEIVE AND COPE WITH STRESS. ANTECEDENT TO THE PSYCHOSOCIAL TRAITS WHICH INFLUENCE STRESSOR APPRAISAL AND STRESS-RESPONSIVE BEHAVIOR, SELF-CONCEPT MAY THEREFORE SERVE AS A VIABLE POINT OF INTERVENING ON THE SUBJECTIVE IDENTITY CHARACTERISTICS WHICH CATALYZE PREMATURE AND DYSFUNCTIONAL AGING IN THE CONTEXT OF SOCIAL DISADVANTAGE AND PREDISPOSE INDIVIDUALS TO CVD. INCORPORATING A GEROSCIENTIFIC PERSPECTIVE