RISK AND RESILIENCE FACTORS IN MEMORY AGING AMONG OLDER CANCER SURVIVORS: A CROSS COUNTRY COMPARISON OF THE…

Assistance award details

Assistance award identifier

ASST_NON_R00AG076532_075

FAIN

R00AG076532

Recipient

MICHIGAN STATE UNIVERSITY

Awarding agency

Department of Health and Human Services

Funding agency

Department of Health and Human Services

Assistance listing (CFDA)

93.866

Total obligated

$483,583

Period

Jun 1, 2023 – May 31, 2028

Fiscal year

2025

Place of performance state

MI

Source file

FY2025_All_Assistance_Full_20261006.zip

Description

RISK AND RESILIENCE FACTORS IN MEMORY AGING AMONG OLDER CANCER SURVIVORS: A CROSS COUNTRY COMPARISON OF THE US AND ENGLAND - MEMORY LOSS IS A HALLMARK SYMPTOM OF ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (ADRD). BY IDENTIFYING ITS EARLY STAGES, INTERVENTIONS COULD BE DEVELOPED TO PREVENT OR SLOW ADRD PROGRESSION. WHILE PREVIOUS RESEARCH HAS EXAMINED MEMORY AGING AMONG THE GENERAL POPULATION, THE LONG-TERM MEMORY AGING OF OLDER CANCER SURVIVORS IS UNDER-STUDIED. THIS IS A CRITICAL EVIDENCE GAP, AS >26 MILLION PEOPLE IN THE UNITED STATES (US) AND >5 MILLION PEOPLE IN THE UNITED KINGDOM (UK) WILL BE CANCER SURVIVORS BY 2040, AND >70% OF CANCER SURVIVORS WILL BE OVER AGE 65. THE US AND UK HAVE DIFFERENT HEALTH CARE SYSTEMS, GOVERNMENT SOCIAL SAFETY NET POLICIES, AND MAGNITUDES OF INCOME INEQUALITY. HENCE, OLDER CANCER SURVIVORS ARE AGING IN DIFFERENT SOCIAL, POLITICAL, AND ECONOMIC ENVIRONMENTS ACROSS THESE TWO HIGH-INCOME COUNTRIES. A CROSS-NATIONAL COMPARISON OF THE US AND UK IS AN OPPORTUNITY TO IDENTIFY DRIVERS OF BOTH INDIVIDUAL-LEVEL VARIATION AND POPULATION-LEVEL DIFFERENCES IN THE MEMORY AGING OF OLDER CANCER SURVIVORS. UNDERSTANDING THE LONG-TERM MEMORY AGING OF OLDER CANCER SURVIVORS IN A CROSS-NATIONAL FRAMEWORK WILL ENHANCE OUR KNOWLEDGE OF WHAT FACTORS MATTER MOST FOR THE MEMORY AGING OF OLDER CANCER SURVIVORS AND COULD BE TARGETS FOR INTERVENTIONS. THIS K99/R00 PROPOSAL LEVERAGES LONGITUDINAL PRE- AND POST-CANCER DIAGNOSIS DATA FROM TWO NATIONALLY REPRESENTATIVE COHORTS, THE US HEALTH AND RETIREMENT STUDY (HRS) AND THE ENGLISH LONGITUDINAL STUDY OF AGEING (ELSA), TO INVESTIGATE LONG-TERM MEMORY TRAJECTORIES OF N=2,500 OLDER CANCER SURVIVORS FROM 2002 TO 2018. THE SPECIFIC AIMS ARE TO: (1) IDENTIFY AND COMPARE MEMORY TRAJECTORIES OF CANCER SURVIVORS IN THE HRS AND ELSA, OVERALL AND BY AGE AND SEX (K99 PHASE); (2) IDENTIFY AND COMPARE INDIVIDUAL, NEIGHBORHOOD, AND MACRO-LEVEL SOCIOECONOMIC INEQUALITIES IN MEMORY AGING OF CANCER SURVIVORS IN THE HRS AND ELS