EARLY CHARACTERIZATION OF COGNITIVE STATUS AND AD RISK IN AFRICAN AMERICAN MEN - PROJECT SUMMARY/ABSTRACT A…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
Assistance award details
- Assistance award identifier
- ASST_NON_R00AG078286_075
- FAIN
- R00AG078286
- Recipient
- UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $241,407
- Period
- Sep 1, 2023 – Aug 31, 2027
- Fiscal year
- 2024
- Place of performance state
- KY
- Source file
- FY2024_All_Assistance_Full_20261006.zip
Description
EARLY CHARACTERIZATION OF COGNITIVE STATUS AND AD RISK IN AFRICAN AMERICAN MEN - PROJECT SUMMARY/ABSTRACT ALTHOUGH PAST STUDIES DONE PRIMARILY ON WHITE AMERICANS REPORT THAT MEN HAVE A HIGHER RISK OF MILD COGNITIVE IMPAIRMENT (MCI) AND MORE RAPID PROGRESSION FROM MCI TO AD, WE DO NOT KNOW IF THIS IS ALSO THE CASE FOR AFRICAN AMERICAN MEN. EARLY CHARACTERIZATION OF COGNITIVE STATUS AND ALZHEIMERâS DISEASE (AD) RISK IN OLDER AFRICAN AMERICAN MEN IS A CRITICAL UNMET CHALLENGE. THERE HAVE BEEN NOTABLY FEW DEMENTIA STUDIES THAT INCLUDED SUBSTANTIAL NUMBERS OF OLDER AFRICAN AMERICAN MEN. IN PARTICULAR, THERE IS A PAUCITY OF NEUROIMAGING DATA ON OLDER AFRICAN AMERICAN MEN IN THE YEARS PRIOR TO, AND DURING, COGNITIVE DECLINE TO AD. WE WILL UTILIZE A CROSS- SECTIONAL STUDY OF OLDER, URBAN AFRICAN AMERICAN MEN TO CHARACTERIZE GENETIC, SOCIAL, AND ENVIRONMENTAL INFLUENCES ON THE BRAIN AND NEURAL MARKERS INDICATIVE OF COGNITIVE STATUS AND AD RISK. MY TRAINING APPLICATION WILL NOT ONLY ADVANCE OUR UNDERSTANDING OF NEURAL CHANGES AND BRAIN ACTIVITY IN OLDER AFRICAN AMERICAN MEN, ESPECIALLY THOSE EXPOSED TO CONDITIONS THAT PUT THEM AT HIGH RISK FOR AD, BUT HOW THEIR BRAIN HEALTH RELATES TO BEHAVIORAL, GENETIC, NEURAL, LIFESTYLE, SOCIAL, AND ENVIRONMENTAL RISK FACTORS. USING OBSERVATIONAL STUDY DURING THE K99 PHASE, I WILL CAPTURE BRAIN AND NEURAL PATHWAYS TO COGNITIVE CHANGES/DECLINE IN AFRICAN AMERICANS, WHILE UNDERGOING EXTENSIVE TRAINING TO GAIN MASTERY OF NEUROIMAGING TOOLS AND CONCEPTS, PROFICIENCY IN EXAMINING BRAIN IMAGE BIOMARKERS, NEUROPSYCHOLOGICAL ASSESSMENTS, AND TASK-BASED FMRI TESTING AND ANALYSES. IN THE R00 PHASE, WE WILL EXAMINE THE NEURAL PATHWAYS THROUGH WHICH SOCIAL AND ENVIRONMENTAL FACTORS IMPACT COGNITION AND IDENTIFY INDIVIDUAL VARIABILITY THAT MODERATES THEIR IMPACT. ALSO, WE WILL EXPLORE IF SOCIAL AND ENVIRONMENTAL INFLUENCES ARE MEDIATED BY THEIR EFFECT ON THE APOE Î4 AND ABCA7-80 GENES TO IMPACT COGNITIVE STATUS AND AD RISK IN OLDER AFRICAN AMERICAN