THE BENEFITS OF NICOTINAMIDE RIBOSIDE UPON COGNITION AND SLEEP IN OLDER VETERANS - PROJECT SUMMARY/ ABSTRAC…

Assistance award details

Assistance award identifier

ASST_NON_R00AG079117_075

FAIN

R00AG079117

Recipient

THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

Awarding agency

Department of Health and Human Services

Funding agency

Department of Health and Human Services

Assistance listing (CFDA)

93.866

Total obligated

$742,020

Period

Sep 1, 2024 – Aug 31, 2027

Fiscal year

2024

Place of performance state

NY

Source file

FY2024_All_Assistance_Full_20261006.zip

Description

THE BENEFITS OF NICOTINAMIDE RIBOSIDE UPON COGNITION AND SLEEP IN OLDER VETERANS - PROJECT SUMMARY/ ABSTRACT CANDIDATE: MY OVERARCHING GOAL IS TO PROMOTE HEALTHY AGING THROUGH QUALITY SLEEP AS AN INDEPENDENT NURSE-SCIENTIST. MY CLINICAL TRAINING IN GERIATRICS AND BEHAVIORAL SLEEP MEDICINE AND MY PRE-CLINICAL FELLOWSHIP IN SLEEP AND CIRCADIAN DISRUPTIONS LAY THE FOUNDATION FOR MY EXPERTISE TO REACH THIS GOAL. THIS PROPOSAL WILL PERMIT TRAINING IN BASIC SCIENCES APPLIED TO HUMAN STUDIES TO SUPPORT THE UNDERSTANDING OF MOLECULAR MECHANISMS OF POOR SLEEP AND COGNITIVE IMPAIRMENT IN OLDER ADULTS AND THEIR UNDERLYING INTERACTIONS. THE CAREER DEVELOPMENT PROPOSED IN THIS APPLICATION WILL EMPOWER MY GROWTH AS AN EMERGING LEADER FROM AN UNDERREPRESENTED BACKGROUND WITH PREVIOUS AWARDS FROM THE SLEEP RESEARCH SOCIETY AND AMERICAN ACADEMY OF SLEEP MEDICINE. MENTORS AND ENVIRONMENT: A PROMINENT TEAM OF MENTORS AND CONSULTANTS HAS BEEN ASSEMBLED FOR THIS PROJECT. MY PRIMARY MENTOR, DR. BRUCE TROEN (GERIATRICS) IS AN INTERNATIONALLY RECOGNIZED GERIATRICIAN AND GEROSCIENTIST. HE WILL BE ASSISTED BY CO-MENTORS DR. REBECCA LORENZ (NURSING, GERIATRIC, SLEEP), DR. BRIENNE MINER (GERIATRICS, SLEEP), DR. KENNETH SELDEEN (GERIATRICS, BIOCHEMISTRY); AND ADVISORS DR. NIKHIL SATCHIDANAND (GERIATRICS, COGNITION), AND DR. CHANG-XING MA (BIOSTATISTICS). WE HAVE CREATED A TRAINING PROGRAM TO NURTURE RESEARCH AND LEADERSHIP SKILLS BASED UPON THE UNIVERSITY AT BUFFALO AND YALE UNIVERSITY PROGRAMS ON GERIATRICS AND SLEEP RESEARCH FOR SUCCESSUL EXECUTION OF THE CAREER DEVELOPMENT AND RESEACH PROJECT OUTLINED IN THIS APPLICATION. MENTORED RESEARCH PROJECT: POOR SLEEP QUALITY AND SHORT SLEEP DURATION ARE ASSOCIATED WITH COGNITIVE IMPAIRMENT IN OLDER ADULTS AND MAY BE CANDIDATE MECHANISM UNDERLYING ALZHEIMER’S DISEASE AND OTHER DEMENTIAS VIA IMPAIRED MITOCHONDRIAL FUNCTION AND/OR A REDUCED EXPRESSION OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF). OUR PREVIOUS WORK INDICATED THAT ENHANCING THE AVAILABI