BRAIN METABOLISM ACROSS THE LIFESPAN USING MULTI-PARAMETRIC MRS - GLOBAL LIFE EXPECTANCY IS RISING, AND 16%…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
Assistance award details
- Assistance award identifier
- ASST_NON_R00AG080084_075
- FAIN
- R00AG080084
- Recipient
- THE JOHNS HOPKINS UNIVERSITY
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $249,000
- Period
- Sep 1, 2023 – Mar 31, 2029
- Fiscal year
- 2026
- Place of performance state
- MD
- Source file
- FY2026_All_Assistance_Full_20261006.zip
Description
BRAIN METABOLISM ACROSS THE LIFESPAN USING MULTI-PARAMETRIC MRS - GLOBAL LIFE EXPECTANCY IS RISING, AND 16% OF THE WORLDâS POPULATION â UP TO 25% IN NORTH AMERICA â IS PREDICTED TO BE AT LEAST 65 YEARS OF AGE BY 2050. AGING SOCIETIES ARE EXPOSED TO INCREASING EMERGENCE OF AGE-RELATED DISEASES SUCH AS ALZHEIMERâS DISEASE AND RELATED DEMENTIAS (AD/ADRD). IDENTIFYING INDIVIDUALS AT RISK USING NEW MARKERS OF PATHOPHYSIOLOGICAL CHANGES WILL BECOME A KEY CHALLENGE OF 21ST CENTURY MEDICINE TO ENABLE PREVENTION AND EARLY INTERVENTION. ESTABLISHING NORMATIVE RANGES OF THESE MARKERS ACROSS THE LIFESPAN IS IMPERATIVE FOR EARLY DIAGNOSTICS AND TO IMPROVE OUR UNDERSTANDING OF HEALTHY AGING AND AD MECHANISMS. PROTON MAGNETIC RESONANCE SPECTROSCOPY (1H-MRS) IS A NON-INVASIVE IN-VIVO METHOD QUANTIFYING SIGNALS FROM ENDOGENOUS METABOLITES, LIPIDS AND MACROMOLECULES (MM). MRS SIGNAL AMPLITUDES ARE DETERMINED BY THE CONCENTRATIONS AND MR RELAXATION TIMES OF THESE COMPOUNDS, I.E. INDICATORS OF LOCAL BIOCHEMISTRY AND CELLULAR MICROSTRUCTURE, RESPECTIVELY. UNFORTUNATELY, SUBJECT-SPECIFIC METABOLITE RELAXATION AND MM ESTIMATION IS PROHIBITIVELY TIME-CONSUMING WITH CONVENTIONAL MRS METHODS, AND RESEARCHERS ARE FORCED TO USE AVERAGED LITERATURE VALUES AND ASSUMPTIONS INSTEAD. THIS PRACTICE IS HIGHLY PROBLEMATIC AS CHANGES IN METABOLITE LEVELS, RELAXATION TIMES AND THE MM BACKGROUND REFLECT DIFFERENT BIOLOGICAL PROCESSES THAT EVOLVE INDEPENDENTLY ACROSS THE LIFESPAN, BUT CANNOT BE DISTINGUISHED USING CONVENTIONAL MRS (E.G., SIGNAL DECREASES WITH AGE COULD REFLECT LOWER METABOLITE LEVELS OR SHORTER TRANSVERSE RELAXATION TIMES). CURRENT MRS METHODS THEREFORE HAVE SUBSTANTIALLY DIMINISHED INTERPRETABILITY IN HEALTHY AGING AND NEURODEGENERATIVE DISEASES SUCH AS ADRD. THIS RESEARCH PROPOSAL WILL ADDRESS THIS CRITICAL KNOWLEDGE GAP BY DEVELOPING NOVEL MRS METHODS ALLOWING SIMULTANEOUS SUBJECT-SPECIFIC METABOLITE CONCENTRATION, RELAXATION TIME, AND MM BACKGROUND ESTIMATION. BY SEPARATING TH