PAIN AND NUTRITION IN DEMENTIA AND ALZHEIMER'S-2 (PANDA-2) - PROJECT ABSTRACT/SUMMARY GROWING EVIDENCE SUGG…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
Assistance award details
- Assistance award identifier
- ASST_NON_R00AG081552_075
- FAIN
- R00AG081552
- Recipient
- UNIVERSITY OF FLORIDA
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $771,765
- Period
- Aug 15, 2024 – Jul 31, 2027
- Fiscal year
- 2024
- Place of performance state
- FL
- Source file
- FY2024_All_Assistance_Full_20261006.zip
Description
PAIN AND NUTRITION IN DEMENTIA AND ALZHEIMER'S-2 (PANDA-2) - PROJECT ABSTRACT/SUMMARY GROWING EVIDENCE SUGGESTS THE PRESENCE OF DYSREGULATED PAIN MODULATION IN OLDER ADULTS, AND AFFECT WHICH MAY HEIGHTEN AGE-ASSOCIATED RISK FOR CHRONIC PAIN. ADDITIONALLY, CHRONIC PAIN AND ALZHEIMERâS DISEASE AND RELATED DEMENTIAS (AD/ADRD) ARE HIGHLY PREVALENT AND COMORBID IN OLDER ADULTS, AND RESEARCH SUGGESTS THAT THEY MAY HAVE OVERLAPPING ETIOLOGIES AND PATHOLOGIES. CHRONIC PAIN MAY A PREDICTOR FOR THE DEVELOPMENT OF AD, AND ALMOST HALF OF AD PATIENTS REPORT HAVING PAIN. THUS, UNDERSTANDING OF THE SHARED MECHANISMS UNDERLYING BOTH IS CRITICAL IN ORDER TO DEVELOP EFFECTIVE TREATMENT AND PREVENTION MODALITIES. RECENTLY, EPIGENETICS HAS BEEN IMPLICATED IN BOTH DISEASE STATES, WITH MANY MODIFICATIONS OF THE EPIGENOME THAT MAY GO ON TO RESULT IN IMMUNE SYSTEM DYSFUNCTION, OF WHICH IS A HALLMARK OF BOTH CHRONIC PAIN AND AD. WHILE THERE ARE MANY ENVIRONMENTAL FACTORS THAT CAN INFLUENCE THE EPIGENOME, NUTRITION STATUS HAS BEEN SHOWN TO BE ONE OF THE MOST COMMON AND MODIFIABLE FACTORS THEREIN. THUS, IT MAY BE EFFICACIOUS TO UNDERSTAND DIETARY INTERACTIONS WITH THE EPIGENOME TO TARGET EPIGENETIC REGULATION OF THE DEVELOPMENT AND MAINTENANCE OF CHRONIC PAIN AND AD. THEREFORE, THE OVERALL GOAL FOR THIS MENTORED CAREER DEVELOPMENT PROPOSAL (K99/R00) IS TO FILL THIS KNOWLEDGE GAP AND DETERMINE THE INFLUENCE OF OVERALL DIET PATTERN AS WELL AS VITAMINS A AND D SPECIFICALLY ON THE EPIGENETIC ENVIRONMENT AS IT RELATES TO CHRONIC PAIN AND AD/ADRD. PRIMARY TRAINING GOALS FOR THE CURRENT PROPOSAL ARE TO: INCREASE KNOWLEDGE AND UNDERSTANDING OF MEASUREMENT TECHNIQUES USED TO ASSESS COGNITIVE AGING IN HUMANS, WITH A SPECIFIC FOCUS ON MILD COGNITIVE IMPAIRMENT, AND AD/ADRD; FURTHER EXPAND KNOWLEDGE OF NUTRI-EPIGENETICS, AND APPLY IT TO COGNITIVE AGING OUTCOMES; ENHANCE CLINICAL RESEARCH SKILLS RELATED TO THE DESIGN, CONDUCT AND STATISTICAL ANALYSIS OF MULTIDISCIPLINARY STUDIES AND RIGOROUS TRANSLATION