PLASMA PROTEOMIC SIGNATURES OF PHYSICAL ACTIVITY AND ALZHEIMER'S DISEASE AND RELATED DEMENTIAS - PROJECT SU…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
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ASST_NON_R00AG082863_075 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · Department of Health and Human Services
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- Assistance award identifier
- ASST_NON_R00AG082863_075
- FAIN
- R00AG082863
- Recipient
- UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $248,647
- Period
- Sep 1, 2023 – Feb 28, 2029
- Fiscal year
- 2026
- Place of performance state
- CA
- Source file
- FY2026_All_Assistance_Full_20261006.zip
Description
PLASMA PROTEOMIC SIGNATURES OF PHYSICAL ACTIVITY AND ALZHEIMER'S DISEASE AND RELATED DEMENTIAS - PROJECT SUMMARY/ABSTRACT PHYSICAL ACTIVITY (PA) HAS BEEN LISTED AS A PROMISING INTERVENTION TO DELAY OR PREVENT ALZHEIMERâS DISEASE (AD) AND RELATED DEMENTIAS (ADRD), HOWEVER MOST STUDIES USED SELF-REPORTED PA. OUR PRELIMINARY DATA SHOW THAT, AMONG OLDER WOMEN, HIGHER AMOUNTS OF ACCELEROMETER-MEASURED MODERATE TO VIGOROUS INTENSITY PA AND STEPS/DAY ARE ASSOCIATED WITH LOWER RISK OF RIGOROUSLY ADJUDICATED INCIDENT MILD COGNITIVE IMPAIRMENT (MCI) AND ADRD. HOWEVER, THE MOLECULAR MECHANISMS THROUGH WHICH PA INFLUENCES ADRD RISK ARE UNCLEAR. THE PLASMA PROTEOME IS A PROMISING TARGET FOR IDENTIFYING THE MOLECULAR MECHANISMS OF PA BECAUSE PROTEINS REGULATE BIOLOGICAL PROCESSES, CAPTURE DISEASE MECHANISMS, AND MAY IDENTIFY INTERVENTION TARGETS. MACHINE LEARNING (ML) METHODS HAVE BEEN APPLIED TO DERIVE PA PROTEOMIC SIGNATURES, PROTEOMIC AGING CLOCKS, AND ADRD PROTEOMIC CLOCKS. HOWEVER, FEW STUDIES HAVE SYSTEMATICALLY APPLIED AND COMPARED ML METHODS TO DERIVE PA PROTEOMIC SIGNATURES. THE OBJECTIVE OF THIS RESEARCH IS TO ENHANCE OUR UNDERSTANDING OF PA, PROTEOMICS, AND HOW THEY RELATE TO ADRD. I PROPOSE LEVERAGING AN NIA-FUNDED STUDY (RF1AG079149) THAT WILL USE THE SOMASCAN PLATFORM TO MEASURE ~7,000 CLINICALLY RELEVANT PLASMA PROTEINS AND PLASMA AD BIOMARKERS IN A CASE COHORT OF 2,836 (N=1,336 INCIDENT MCI/ADRD CASES) WOMEN IN THE RICHLY PHENOTYPED AND RACIALLY/ETHNICALLY DIVERSE WOMENâS HEALTH INITIATIVE (WHI) MEMORY STUDY (WHIMS) FROM SAMPLES COLLECTED IN 1995-1998 (N=2,836) AND 14-18 YEARS LATER IN 2012-2013 (N=1,000; 500 INCIDENT MCI/ADRD CASES) AND THE WHI OBJECTIVE PHYSICAL ACTIVITY AND CARDIOVASCULAR HEALTH (OPACH; R01HL105065) STUDY WHICH COLLECTED ACCELEROMETRY IN 2012-2014 AMONG 6,489 WOMEN, INCLUDING THE 1,000 WHIMS WOMEN IN RF1AG079149. WHIMS CONTAINS LONGITUDINAL ANNUAL COGNITIVE ASSESSMENTS AND RIGOROUSLY ADJUDICATED MCI/DEMENTIA OVER 27 YEARS OF FOLLOW-UP. IN