MODIFIABLE RISK FACTORS AND MIDLIFE COGNITION IN DIVERSE POPULATIONS: A POOLED COHORT STUDY - PROJECT SUMMA…

Assistance award details

Assistance award identifier

ASST_NON_R00AG083211_075

FAIN

R00AG083211

Recipient

NEW YORK UNIVERSITY

Awarding agency

Department of Health and Human Services

Funding agency

Department of Health and Human Services

Assistance listing (CFDA)

93.866

Total obligated

$248,999

Period

Jul 1, 2024 – Jul 31, 2029

Fiscal year

2026

Place of performance state

NY

Source file

FY2026_All_Assistance_Full_20261006.zip

Description

MODIFIABLE RISK FACTORS AND MIDLIFE COGNITION IN DIVERSE POPULATIONS: A POOLED COHORT STUDY - PROJECT SUMMARY WITH THE LACK OF DISEASE-ALTERING TREATMENT IN ALZHEIMER’S DISEASE AND ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (AD/ADRD), TIMELY IDENTIFICATION OF HIGH-RISK INDIVIDUALS AND PREVENTION TARGETING EARLY STAGES OF COGNITIVE DECLINE, HAS BECOME A PROMISING APPROACH AND A PUBLIC HEALTH PRIORITY TO REDUCE THE CARE AND COST BURDEN OF AD/ADRD. OVER THE LIFECOURSE, MIDLIFE (AGE 40-65 YEARS) IS A CRITICAL AND YET UNDERSTUDIED PERIOD WHEN COGNITIVE FUNCTION BEGINS TO DECLINE, AND THE IMPACT OF MODIFIABLE RISK FACTORS (MRFS) BECOMES PROMINENT. MRFS AND AD/ADRD DISPROPORTIONATELY IMPACT RACE/ETHNIC MINORITIES IN THE UNITED STATES (US). HOWEVER, RACE/ETHNIC MINORITIES REMAIN UNDERREPRESENTED IN AD/ADRD RESEARCH, AND FUNDAMENTAL GAPS EXIST IN UNDERSTANDING THE JOINT ROLE OF MRFS, WHICH OFTEN CO-OCCUR, IN RACE/ETHNIC DISPARITIES IN COGNITIVE AGING, ESPECIALLY IN MIDLIFE. FURTHERMORE, WHETHER THE RELATIONSHIPS BETWEEN MRFS AND MIDLIFE COGNITIVE DISPARITIES IN DIVERSE POPULATIONS ARE MEDIATED BY VASCULAR, INFLAMMATORY, AND NEURODEGENERATIVE PATHWAYS NEEDS TO BE ELUCIDATED. THE OVERARCHING GOAL OF THIS RESEARCH PROGRAM IS TO ENHANCE OUR UNDERSTANDING OF THE ROLES AND MECHANISMS OF MRFS IN RACE/ETHNIC DISPARITIES IN COGNITION DURING MIDLIFE AND EXPLORE UNDERLYING MECHANISTIC PATHWAYS. USING A FEASIBLE AND COST-EFFECTIVE APPROACH, THIS PROJECT WILL LEVERAGE THE STRENGTH OF THREE NIH- FUNDED LONGITUDINAL COHORT STUDIES IN DIVERSE POPULATIONS, THE CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS STUDY, THE HEALTH AND AGING BRAIN STUDY: HEALTH DISPARITIES, AND THE WISCONSIN REGISTRY FOR ALZHEIMER’S PREVENTION. WITH MORE THAN 5,000 BLACK, HISPANIC, AND WHITE MIDDLE-AGED ADULTS, ALL THREE COHORTS ALSO HAVE STATE-OF-THE-ART MEASUREMENTS OF MRFS, COGNITIVE FUNCTION, AND MARKERS OF VASCULAR, INFLAMMATORY, AND NEURODEGENERATIVE PATHWAYS. INNOVATIVE AND RIGOROUS EPIDEMIOLOGIC AND S