APPLICATION OF PRECISION MEDICINE TO PHOTOTHERAPY: A STEPPED CARE APPROACH TO CONSOLIDATE SLEEP AND SLOW CO…
Federal financial assistance recorded from USAspending. This is not a procurement contract.
Assistance award details
- Assistance award identifier
- ASST_NON_R00AG084846_075
- FAIN
- R00AG084846
- Recipient
- THE REGENTS OF THE UNIVERSITY OF COLORADO
- Awarding agency
- Department of Health and Human Services
- Funding agency
- Department of Health and Human Services
- Assistance listing (CFDA)
- 93.866
- Total obligated
- $248,999
- Period
- Aug 9, 2024 – Dec 31, 2028
- Fiscal year
- 2026
- Place of performance state
- CO
- Source file
- FY2026_All_Assistance_Full_20261006.zip
Description
APPLICATION OF PRECISION MEDICINE TO PHOTOTHERAPY: A STEPPED CARE APPROACH TO CONSOLIDATE SLEEP AND SLOW COGNITIVE DECLINE IN OLDER ADULTS - PROJECT SUMMARY/ABSTRACT WHILE CONSOLIDATED SLEEP IS CRUCIAL FOR HEALTHY COGNITION AND MOOD IN OLDER INDIVIDUALS, MANY SUFFER FROM SLEEP- WAKE FRAGMENTATION, A RISK FACTOR FOR DEVELOPING ALZHEIMER'S DISEASE. ONE COUNTERMEASURE OF SLEEP-WAKE FRAGMENTATION IS EXPOSURE TO BRIGHT LIGHT ( PHOTOTHERAPY ). STUDIES USING MORNING PHOTOTHERAPY, WHICH TARGETS CIRCADIAN PHASE, TO RESTORE SLEEP-WAKE FRAGMENTATION HAVE REPORTED MIXED RESULTS. HOWEVER, BOTH MATHEMATICAL MODELS OF THE CIRCADIAN PACEMAKER AND DATA FROM OUR LAB SUGGEST THAT AFTERNOON LIGHT EXPOSURE, TARGETING CIRCADIAN AMPLITUDE, WILL HAVE GREATER EFFECTS ON SLEEP-WAKE CONSOLIDATION. SINCE PHOTOTHERAPY CAN BE ADMINISTERED WITHOUT SIGNIFICANT ADVERSE EFFECTS, IT IS A PROMISING TOOL TO REVERSE SLEEP-WAKE FRAGMENTATION AND SLOW COGNITIVE DECLINE. THEREFORE, THE OVERARCHING GOAL OF THE PROPOSED STUDIES IS TO SLOW COGNITIVE DETERIORATION IN OLDER INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT (MCI) BY INVESTIGATING THE UTILITY OF AFTERNOON PHOTOTHERAPY. THE RESEARCH TRAINING PLAN WILL LEVERAGE STATE-OF-THE-ART ARTIFICIAL INTELLIGENCE TECHNIQUES ON BIG DATASETS (SPECIFIC AIMS 1 AND 3) AND AN INTERVENTION CLINICAL TRIAL (SPECIFIC AIM 2). IN AIM 1 (K99), THE APPLICANT, DR. LOK, WILL TRAIN WITH DR. KOCHENDERFER AS SHE APPLIES STATE-OF-THE-ART MACHINE LEARNING TECHNIQUES TO DETERMINE UNDERLYING FACTORS CONTRIBUTING TO SLEEP-WAKE FRAGMENTATION AND COGNITIVE DECLINE. DURING THIS TIME, DR. LOK WILL ALSO LEARN TO CONDUCT NEUROCOGNITIVE TESTING IN INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT. DR. LOK WILL CONDUCT A CLINICAL TRIAL (R00), INVESTIGATING THE UTILITY OF AFTERNOON PHOTOTHERAPY IN A STEPPED CARE APPROACH TO REDUCE SLEEP- WAKE FRAGMENTATION AND IMPROVE COGNITION. FINALLY, DR. LOK WILL USE MACHINE-LEARNING TECHNIQUES TO DEVELOP A PERSONALIZED PHOTOTHERAPY MODEL TO CREATE A PREDICTION SCORE C