INTRODUCTION AND BACKGROUND COMBIMATRIX PROPOSES TO DEVELOP A FULLY AUTOMATED, MINIATURIZED, AND INTEGRATED…
Award details are derived from public USAspending.gov records. Not a bid recommendation.
Award details
- Award ID
- NNA09DA96C
- Contractor
- Awarding agency
- National Aeronautics and Space Administration
- Sub-agency / office
- National Aeronautics and Space Administration
- Award amount
- $0
- Period of performance
- Apr 28, 2009 – Mar 10, 2013
- NAICS
- 541711 — Research and Development in Biotechnology
- PSC
- PSC 1830
- Place of performance
- WA
Public award description
INTRODUCTION AND BACKGROUND COMBIMATRIX PROPOSES TO DEVELOP A FULLY AUTOMATED, MINIATURIZED, AND INTEGRATED SYSTEM FOR THE IN SITU MEASUREMENT OF GENE EXPRESSION IN BACTERIAL CULTURES EXPOSED TO SPACE. THE SPACE ENVIRONMENT OFFERS UNIQUE STRESSORS TO CELLULAR METABOLISM NOT FOUND ON EARTH, INCLUDING: MICROGRAVITY AND COSMIC RADIATION. PRIMARY SOURCES OF DATA FOR UNDERSTANDING HOW ORGANISMS RESPOND TO DIFFERENT STRESSFUL CONDITIONS ARE MEASUREMENTS OF GENE EXPRESSION IN CELLS AS DEFINED BY LEVELS OF RNA TRANSCRIPTS. CURRENT PROTOCOLS FOR MEASURING CHANGES IN GENE EXPRESSION DURING SPACE FLIGHT CALL FOR FIXING MICROORGANISMS IN SPACE AND CARRYING OUT SAMPLE PREPARATION AND GENE EXPRESSION MEASUREMENTS ON THE GROUND. THE PROPOSED INSTRUMENT WILL HANDLE ALL THE REQUIRED STEPS AUTOMATICALLY IN SPACE IN SPECIALLY DESIGNED FLUIDIC CARTRIDGES, WHICH ENABLES NEAR-TIME MEASUREMENTS CONTINUOUSLY OVER WEEKS OR MONTHS.
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