HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)

Opportunity details

Agency

National Institutes of Health

Notice type

Federal Grant

Original posted

September 28, 2026

Last updated

October 18, 2026

Notice ID

grant-361304

Summary

The NIH Helping to End Addiction Long-term® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The phased projects supported by this program (of up to five years total in duration) will first identify and validate multi-tissue mechanisms underlying joint pain, then test non-pharmacologic or multimodal interventions that directly target these mechanisms. The initiative responds to priorities identified in the 2023 HEAL Whole Joint Pain Workshop and supports the broader goals of the NIH HEAL Initiative and the Make America Healthy Again vision by advancing safe, non-addictive, and prevention-oriented approaches to chronic pain.

Summary fields are from official SAM.gov or Grants.gov structured data. CaptureIQ does not republish full solicitation or grant text.

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Eligible applicant categories

• State governments
• County governments
• City or township governments
• Special district governments
• Independent school districts
• Public and State controlled institutions of higher education
• Native American tribal governments (Federally recognized)
• Public housing authorities/Indian housing authorities
• Native American tribal organizations (other than Federally recognized tribal governments)
• Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
• Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
• Private institutions of higher education
• For-profit organizations other than small businesses
• Small businesses
• Others (see text field entitled "Additional Information on Eligibility" for clarification)

Official Grants.gov eligibility information. Listed categories are not a determination that an organization qualifies.

Funding and program

Assistance Listing

93.121

Funding instrument

G

Cost sharing

Not required

Official modification date

September 28, 2026

These figures are estimates, not guaranteed funding.

Related Federal Opportunities

• Global Collaborative Research Training on Non-Communicable Diseases and Disorders Across the LifespanNational Institutes of Health
• Limited Competition: Small Grant Program for the NCATS Clinical and Translational Science Award (CTSA) Program (Clinical Trial Optional)National Institutes of Health
• Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)National Institutes of Health
• NLM Institutional Grants for Research Training in Biomedical Informatics, Data Science, and AI (T15 Independent Clinical Trial Not Allowed)National Institutes of Health · Due Feb 11, 20