Biologically-Derived Targeted Antifungals for Textile Applications

Fungal skin infections plague active duty servicemembers at elevated rates due to exposure to warm, humid climates, poor skin hygiene, and close-quarters living arrangements. We have developed a novel solution that incorporates an endophytic fungal extract with selective activity against Trichophyton species of pathogens. In addition, the selected compound has negligible impact on the organisms that natural inhabit skin. This approach offers the potential for effective control of fungal skin pathogens while preserving benefits of a healthy skin microbiome, and limiting the development of resistant organisms. Our phase I effort successfully demonstrated proof of concept for incorporation of the compound onto fabrics. In phase II, we will refine the design and complete testing of antifungal fabric performance, durability, and safety. In addition, we will optimize the manufacturing process for large-scale production.