SBIR/STTR Research Award
Fast Parameter Identification for Personalized Pharmacokinetics
Award amount
$149,991Program and phase
STTR · Phase IAward year
2018Award details
- Awarding agency
- Department of Defense
- Branch
- Defense Health Agency
- Recipient company
- AUTONOMOUS HEALTHCARE INC.
- Proposal award date
- 2018-04-09
- Contract end date
- 2019-01-08
- UEI
- MTDYDS8M2176
- Solicitation number
- 17.B
- Topic code
- DHP17B-003
Research abstract
Drug dosingcan bemademore precise by using pharmacokineticand pharmacodynamicmodeling. Pharmacokinetics is thestudy of the concentration of drugs in tissueasafunction of timeand doseschedule,whereas pharmacodynamics is thestudy of therelationship between drugconcentration and drugeffect. By relating doseto resultant drugconcentration (pharmacokinetics)and concentration to effect (pharmacodynamics),amodel for drug dosingcan begenerated.We proposeto develop acomputational frameworkfor system identification of pharmacokineticmodels,where we will usecompartmental dynamical systemsasageneral frameworkto model pharmacokinetics. A constrained optimization problem is formulated to find optimal parameters of thecompartmental model. A GPU-based numerical solver will be used to solvetheconstrained optimization problem.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Noncontact Monitoring for the Detection of Opioid-Induced Respiratory Depression
- Using Machine Learning and Blockchain Technology to Reduce Drug Diversion in Hospitals
- Noncontact Remote Monitoring for the Detection of Opioid-Induced Respiratory Depression
- TOPIC 425 - COMPUTER VISION-BASED ANALYSIS OF GAIT FOR THE ASSESSMENT OF GERIATRIC CANCER
- An Automated System for Hemorrhage Control and Resuscitation at Point of Injury
Research funding history
17 SBIR/STTR records share this UEI (2013–2025). Reported award amounts total $7,935,965. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services, Department of Defense, National Science Foundation, National Aeronautics and Space Administration