Reducing the foot print and manufacturing cost of Oxygen Imager JIVA-25

Abstract Approximately two third of cancer patients are treated with radiationeither alone or in combination with chemotherapy or surgeryRadiation can damage normal cells and this damage can lead to long term side effectsThereforereduction in overall delivered radiation is beneficial to patientsquality of life and can potentially save healthcare costOxygen guided radiation therapyOGRTis expected to reduce the high radiation dose volume by reducing the dose to well oxygenated tumor tissuethus preserving the structure and integrity of irradiated tissues and reducing side effectsCurrentlythere is no widely available noninvasive clinical or preclinical method to map oxygen partial pressurepOwith high accuracyAvailable methods either do not provide absolute oxygen measurement deep inside the bodyor are not suitable for three dimensional oxygen map acquisitionAbsence of preclinicalanimaloxygen imaging data is the major impediment in development of evidence base for advancing oxygen based treatments into clinicsThereforeproviding research community with oxygen imaging instruments and services is the first step in achieving these goalsThis Phase I SBIR grant will transition the research lab based low frequencymTMHzelectron paramagnetic resonance oxygen imagingEPROIequipment to a commercial benchtop unitJIVAEPROI is a non invasive oxygen imaging technique with pOresolution oftorr and spatial resolution ofmmIt has been widely applied to map hypoxia in animal solid tumors to evaluate the efficiency of anti tumor drugs and recentlyto guide tumor radiation therapyIn aimwe will develop acquisition and image processing software and other accessories that will make JIVAa turnkey instrumentthat can be operated by a technician with no prior experience in EPROIIn aimwe will construct an oxygen imager prototypeJIVAand develop standard operating procedure and manualThe success of this proposal will result in a commercial oxygen imager for cancer research in cancer centersuniversities and pharmaceutical industryOur long term goal is to combine this technology with clinical image guided radiation therapyIMRTequipment for enhanced and targeted radiation therapy Narrative Oxygen is the single most important molecule for aerobic life formsNo reliable preclinical noninvasive method for three dimensional molecular oxygen mapping is currently available to scientists for expanding radiation treatment and cancer biology researchThis proposal is designed to bridge this gapWe will develop a prototype of oxygen imager based on low frequency electron paramagnetic resonance oxygen imagingEPROItechnique for preclinical applications