Wavefront guided customized soft contact lens for highly aberrated eyes

The ultimate goal of this Fast Track small business research project is to improve the vision of people who have abnormal corneal conditions that substantially alter the corneal shape such as keratoconus and corneal transplantPatients with abnormal corneal shapes have substantially larger magnitudes of both lower order and higher order aberrations compared to normalsEven with optimal sphero cylindrical correctionthe uncorrected residual higher order aberrations cause a clinically significant degradation in visual qualityCorrecting the higher order aberrations has been challenging due to both the inability to measure highly aberrated eyes and to manufacture a contact lens with an irregularnon rotationally symmetricalsurface profileThis research project is designed to address these current barriers by developing a commercial gradelarge dynamic range wavefront sensortogether with freeform machining technology to fabricate wavefrontguided customized soft contact lensesIn Phasewe will demonstrate the feasibility of freeform machining technology to create an irregularnon rotationally symmetricallens surface profile capable of correcting higher order aberrationsPhaseAimand minimizing unpredictable translation and rotation of the lens on eye by customizing the back surface of the lens matched to the irregular anterior surface of the corneaPhaseAimIn PhaseAimwe will develop a commercial grade large dynamic range wavefront sensor equipped with user friendly software for wavefront analysis and contact lens designIn PhaseAimwe will evaluate methods to maximize the visual benefit with the wavefront guided lens by minimizing the adverse impact of residual lens movement on correction performanceThenin PhaseAimwe will compare the visual outcomes with this customized soft contact lensCustomEyesto those with soft contact lenses designed to fit keratoconic eyes but with conventional sphero cylindrical optics to determine the clinical feasibility and the true visual benefit provided by the wavefront guided customized soft lens in keratoconus patients