Renal clearable NIR-emitting gold nanoparticles for early detection of drug-induced nephrotoxicity

Summary The objective of this proposal is to demonstrate a unique imaging application of renal clearable near infrared emitting gold nanoparticlesNIR emitting AuNPsin the early detection of druginduced kidney injuries in the preclinical settingsOur central hypothesis is that efficient renal clearance and strong NIR emission of the AuNPs we recently invented will allow us to detect drug induced kidney injuries rapidly and noninvasively at early stages that very few conventional fluorescent contrast agents can doAs a proof of conceptwe will use cisplatina widely used chemotherapeutic drugto induce dose dependent kidney injuries in a CDmouse modelquantify the biocompatibility of NIR AuNPs to CDmice with kidney injuriesand noninvasively stage drug induced kidney injury using in vivo fluorescence imaging techniqueSuccess of this application will enable ClearNano Incto have unique competitiveness in contrast agent market as well as help pharma and biotech companies to evaluate potential nephrotoxicity of drug candidates at a lower cost