SBIR/STTR Research Award

Prodrug treatment for CML

Award identifier 14fab58095b61f22a2f4685b2e4b4fb6fd741626d1b6be2f312cded3660d6fe0Awarding agency Department of Health and Human Services · National Institutes of Health

Award amount

$284,778

Program and phase

SBIR · Phase I

Award year

2017

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Award details

Awarding agency
Department of Health and Human Services
Branch
National Institutes of Health
Recipient company
ABLi Therapeutics, Inc.
Proposal award date
2017-09-06
Contract end date
2018-08-31
UEI
Z6F2VWKXRXL9
Solicitation number
PA16-302
Topic code
102

Research abstract

Inhibikase Therapeutics is a clinical stage bio pharmaceutical company that has developed a novel prodrug formulation for the popular anticancer agent Gleevec Gleevec treatment is commonly accompanied by significant burdensome gastrointestinal side effects that erode therapy success due to poor patient compliance Inhibikaseandapos s prodrug of Gleevec completely blunts these gastrointestinal side effects in comparative toxicology testing in non human primates This suggests that a Gleevec prodrug could substantially benefit patients undergoing treatment for Chronic Myelogenous Leukemia Given that Gleevec is now generic there is little commercial motivation to introduce innovations into the treatment landscape for this devastating disease which now afflicts more than patients in the U S The prodrug could be approved in under two years on a b regulatory guideline bringing urgently needed relief from adherence related side effects to these critically ill patients Inhibikase Therapeutics is a clinical stage bio pharmaceutical company developing a novel strategy for treating cancer using new Gleevec like agents with substantially improved safety and efficacy Up to patients annually could benefit from these agents

Technology keywords

Not reported

Other awards by this recipient

Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.

Awards with the same topic code

Verified by an exact topic code match. This is not a text-similarity match.

Research funding history

9 SBIR/STTR records share this UEI (2009–2021). Reported award amounts total $13,235,709. Reported amounts are not federal obligations.

Phases: Phase II, Phase I, Phase II – Direct to Phase II

Agencies: Department of Health and Human Services

Agency intelligence

Department of Health and Human Services

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