SBIR/STTR Research Award
Urine Diagnostics for Aspergillosis
Award amount
$1,844,235Program and phase
STTR · Phase IIAward year
2017Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- PEARL DIAGNOSTICS, INC.
- Proposal award date
- 2017-07-18
- Contract end date
- 2019-06-30
- UEI
- N9CGVFYJM1B5
- Solicitation number
- PA16-303
- Topic code
- NIAID
Research abstract
Invasive aspergillosisIAcontinues to cause morbidity and death in medically immune
compromised patientslargely because we lack sensitive diagnostic tests that are easy to
use during high risk periodsWe discovered that fungal galactofuranose containing
antigens are excreted in urine of infected animals and peopleusing a novel monoclonal
antibodymAbIn a phase I STTRwe engineered a lateral flow deviceLFDcalled
AspUTestand performance was tested using urine samples obtained from patients with
suspected and confirmed IAResults showed rtsensitivity and specificitymeeting
predefined metrics for continued developmentThis Phase II application is designed to
meet the following Specific AimsTo optimize production of the AspUTest deviceTo
determine performance characteristics of AspUTest as an aid to diagnose invasive
aspergillosis using batched samples obtained from patients with hematological
malignanciesandTo validate and test the performance of AspUTest in clinical
microbiology laboratoriesMeeting these aims will enable submission for FDA clearance
of AspUTestmarking an important advance towards decreasing IA morbidity with
expanded availability of a low costeasy to use urine diagnostic
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- A Point of Care Urine Test to Aid Diagnosis of Aspergillosis
- MycoMEIA - Urine Diagnostic for Aspergillosis
- SBIR Phase I: Novel and Enhanced Urine Test for the Detection of The Fungal Infection Aspergillosis
- Urine Diagnostics for Aspergillosis
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Manufacturing and Formulation Process Development for a Prophylactic Cholera Phage Cocktail
- A first-in-class product for the clearance of high-risk human papillomaviruses
- A Rapid, Point-of-Care Diagnostic to Identify Viable Sexually Transmitted Infections, Reduce Overtreatment, and Prevent Emerging Antibiotic Resistance
- Optimization, Pharmacokinetics, and Efficacy of an IgG Protease for the Treatment of Immune Thrombocytopenia and Other IgG-Mediated Autoimmune Diseases
- Nebulized ALX1 as a treatment for Pseudomonas aeruginosa infections in bronchiectasis patients
Research funding history
5 SBIR/STTR records share this UEI (2015–2025). Reported award amounts total $4,208,302. Reported amounts are not federal obligations.
Phases: Phase II, Phase I, Phase II – Direct to Phase II
Agencies: Department of Health and Human Services, National Science Foundation