Cognitive Change Battery: An Assessment for Serial Administration

ABSTRACT Detecting change in neuropsychological functioning over time is critical for proper diagnosis and management of many neurological psychiatric and psychological conditions It is well documented that most commonly used cognitive assessments produce significant retest effects such as practice and regression to the mean effects Retest effects can cause substantial changes in test scores between assessments and make it virtually impossible to distinguish between true changes in cognitive performance and changes caused by repeated testing Failure to account for such retest effects can lead to diagnostic disagreements failure to detect deleterious effects of an illness or injury or inappropriate attribution of improved scores to recovery or response to treatment In this Phase I STTR application we propose to develop and evaluate the Cognitive Change Battery CCB a non verbal tablet based cognitive assessment instrument for serial neuropsychological evaluations The CCB adopts novel cognitive tasks that are resistant to practice effects and integrates them with a Bayesian regression model to correct for regression to the mean and remaining practice effects The complete test battery will measure four psychometrically distinct cognitive domains working memory long term memory processing speed and executive inhibition The resulting battery will provide clinicians with an instrument that a allows valid assessments of a patient s initial neurocognitive status delivered as a composite score reflecting general cognitive performance and subtest scores for the four distinct cognitive domains b enables unambiguous interpretation of changes in neurocognitive status over time and c is composed of cognitive tests that do not require language and are therefore suitable for non English speaking and language impaired populations Phase of this project will determine the psychometric qualities of the CCB including the absence of retest effects in a sample of N subjects For Phase of this project we will develop additional tests so that each cognitive domain will be represented by at least two subtests and establish population norms for adults age to years NARRATIVE Current neurocognitive assessment batteries are ill suited for repeated administration due to significant retest effects We plan to develop and evaluate an innovative tablet based cognitive battery the Cognitive Change Battery CCB The CCB will provide the clinician with an easy to use psychometrically sound repeatable assessment instrument that will improve diagnostic accuracy and management of neurological and psychiatric conditions