Development of a Low Profile Dual Hormone Patch Pump with Novel Occlusion Sensor

Development of a Low Profile Dual Hormone Patch Pump with Novel Occlusion Sensor Project Summary The Specific Aim of this project is to develop a discrete low profile dual hormone drug delivery system using SFC Fluidics enabling microfluidic technologies A dual ePump will be developed in which a single ePump body will independently and accurately deliver both insulin and glucagon from two separate reservoirs Latching micro valve sets will independently and safely control the delivery of each hormone and a flow confirmation sensor will identify dosing errors from either occlusions or electrical mechanical failures Phase I will see the development of an early prototype with control system and a dosing accuracy of for nL to L dosing volumes will be targeted During Phase II SFC Fluidics will work closely with clinicians and drug formulation glucose sensor and control algorithm developers to develop a robust and reliable artificial pancreas Project Narrative The proposed dual drug delivery system will have the necessary safety features and low dose accuracy to meet the need for insulin and glucagon dual hormone delivery to type diabetics including children and adolescents to greatly improve the quality of life for this significant and growing at risk group