High Sensitivity, Low Complexity, Multiplexed Diagnostic Devices

Infectious diseases have been a constant cause of non-battlefield injury and illness for military personnel engaged in operations throughout theworld. Detection of these infectious pathogens is critical to proper patient care and management of outbreaks, yet many existing diagnostic testsfail to provide adequate sensitivity and/or simplicity for use in forward locations or in isolated areas. We propose to develop a solution for ahigh-sensitivity, low-complexity multiplexed POC diagnostic testing that addresses and resolves each of these challenges through the applicationor our unique and differentiated technologies. At the heart of this concept is our patent pending Specimen Delivery System (Paratus SDS) thatwill allow for the acquisition of a relevant quantity of patient specimen (including swab, blood or urine) by a medic or other military personnel,perform sample preparation and deliver the sample on to a unique paper-based analytical device (PAD) integrated into the cartridge formultiplexed detection of diverse pathogens (viral, bacterial, and protozoan). A reusable mating adapter will extend functionality by magneticspecimen separation and concentration, as well as smartphone-based imaging and App-based notification of results to the warfigther that theyhave tested positive/negative for a particular condition that requires further medical evaluation.