High speed Intraoperative Assessment of Breast Tumor Margin using MarginPAT

After a breast conserving therapy histology is often performed to check whether the excised tumor specimen is surrounded by a sufficient amount of normal tissue If a positive margin is identified then a second operation will be performed Currently the re operation rate is which raises a need for intraoperative detection of residual cancers The current intraoperative tools for margin assessment are time consuming and lack sufficient tumor specificity Multiple emerging optical technologies improved the sensitivity and specificity but still suffered from a long procedure time We propose a multi modal spectroscopic photoacoustic ultrasound imaging system to differentiate cancer and normal tissue in a resected breast tissue Providing both chemical content and mechanical property information this system named MarginPAT is able to measure map tissue components including blood fat fibrosis tissue and breast lesion Based on a compact Raman laser and a high speed scanning chamber the proposed MarginPAT system is able to scan cm tissue area per min which is faster than the frozen section analysis gold standard for intraoperative assessment by one order of magnitude Such capacities allow dimensional assessment of margin status in the entire excised tissue with andgt sensitivity and specificity As breast conserving surgery or lumpectomy is well accepted for the breast cancer treatment a highly sensitive tool is critically needed for intraoperative margin assessment We propose a multi modal photoacoustic ultrasound imaging system for high speed high sensitivity intraoperative margin assessment