SBIR/STTR Research Award
Producing Novel Biosynthetic Therapeutics from Extreme Microbiomes
Award amount
$143,740Program and phase
SBIR · Phase IAward year
2016Award details
- Awarding agency
- Department of Defense
- Branch
- Office for Chemical and Biological Defense
- Recipient company
- iXpressGenes, Inc.
- Proposal award date
- 2016-08-17
- Contract end date
- 2017-02-17
- UEI
- TSJKJXX5GNN8
- Solicitation number
- 2015.2
- Topic code
- CBD152-004
Research abstract
Environmental DNA from three extreme samples will be isolated, cloned into a fosmid library (5760 clones) for sequencing. The sequencing datawill cover ~ 240 Megabases and will be assembled into contigs long enough (~ 40 Kilobases) to represent potential biosynthetic gene clusters(BGCs). This data will be compared to BGC databases looking for homology to antibiotic targets of DoD interest and with reasonable expressionprofiles. Subcloning and expression will be performed on BGC clones of interest followed by inhibitory growth assays to prove in vitro antibacterialactivity. The Option period will be used to test the antibacterial cell extracts against DoD pathogens at the Core facility.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Producing Novel Biosynthetic Therapeutics from Extreme Microbiomes
- Macromolecule Crystallization Screening Results Analysis
- Macromolecule Crystallization Screening Results Analysis
- Fluorescence Intensity-based Scoring of Macromolecule Crystallization Plates
- Fluorescence Anisotropy-based Macromolecule Crystallization Screening
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Exploiting Microbiome and Synthetic Biology to Discover and Produce Naturally Occurring Antibiotics
- Concurrent identification of Natural Antibiotics-Producing Gene Clusters and Culture Conditions
Research funding history
9 SBIR/STTR records share this UEI (2006–2017). Reported award amounts total $4,039,932. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services, Department of Defense, National Science Foundation