An Integrative Approach to Control Group Creation for Prevention Research

DESCRIPTION provided by applicant The goal of this SBIR project is to develop a method for creating algorithmically generated control groups These will be composed of synthetic cases that have two characteristics pretest similarity to whatever prevention treatment group may present itself and patterns of change over time that closely mimic the normal course of alcohol and drug use development The field of alcohol and drug prevention is one that has significantly matured and has rich data resources that can be employed to this end Notably numerous school and community efficacy studies have employed control groups in randomized control trials Additional etiological and epidemiological studies have collected similar data Given the large amount of data available for analysis it is now possible to model the onset of alcohol and drug use among adolescents We propose to gather data from previous studies and develop statistical models that can be used to predict the onset of alcohol and drug use An algorithm will be developed that will create integrative control cases to match to a treatment groupandapos s demographics and pretest mediating variable scores and then estimate future drug use Several benefits of this method are anticipated Alcohol and drug prevention researchers and practitioners will be able to use this approach to test the effectiveness of disseminated interventions and to quickly evaluate the potential of new and alternative prevention interventions Specifically this method will provide a means to evaluate the effectiveness of alcohol and drug prevention programs that are disseminated when randomization cannot occur This method will also make evaluating new and adapted programs easier by reducing the challenges of recruitment subject retention and onsite data collection and pretest non equivalence that often occur when l classrooms schools and communities are assigned to condition PUBLIC HEALTH RELEVANCE This project will address evaluating interventions that address alcohol and drug use and abuse Methods will be developed to allow researchers and practitioners to evaluate programs that are being publicly disseminated to assess their effectiveness Researchers will also be able to use this method to quickly evaluate newly developed or adapted prevention programs