Point-of-Care Rapid RNA test for HIV

Point of Care Rapid RNA test for HIV CrossLife Technologies Inc Project Summary Abstract Current antibody point of care tests cannot distinguish between a motherandapos s and babyandapos s antibodies to detect if an infant has become infected with Human Immunodeficiency Virus HIV According to a recent joint WHO UNAIDS UNICEF report only an estimated percent of babies born to HIV positive mothers obtained an HIV test within the first two months Therefore there are unmet needs for new and improved diagnostics that can be applied at the point of care to detect HIV infections A highly sensitive simple paper strip molecular test that detects HIV at the point of care will be developed The target sequences are amplified using the TARA Template Assisted Rapid Assay technology which is composed of a template dependent chemical transfer reaction with high turnover gold nanoparticle HRP and lateral flow readout The test should be rapid andlt minutes and results in the appearance of colored bands that are detectable by eye or are captured using a smartphone scanner Point of Care Rapid RNA test for HIV CrossLife Technologies Inc RESEARCH andamp RELATED Other Project Information Narrative Globally it is estimated that more than million people living with the human immunodeficiency virus HIV and acquired immune deficiency syndrome AIDS in over half of them were women Early Infant Diagnosis EID of HIV has become a new priority for the US President Emergency Plan for AIDS Relief PEPFAR since The proposed research will enable more sensitive accurate point of care detection of HIV in order to improve public health