An Open Source Precision Medicine Platform for Cloud Operating Systems

DESCRIPTION provided by applicant Rapid improvements in DNA sequencing and synthesis have the potential to usher in a new era of precision medicine To realize this vision however we must re imagine the computational and storage infrastructure used to manage and extract actionable results from the massive data sets made possible by widely available advances in DNA sequencing and synthetic biology In conjunction with the Global Alliance for Genomics and Health GA GH we propose to build the Arvados platform so that a new ecosystem of clinical decision support applications will be able to navigate petabytes of global biomedical data and search millions of genomes in real time seconds Our team has a proven track record of commercial success and high impact scientific research Commercialization of this free and open source software FOSS platform which will be greatly accelerated by this grant will permit organizations to seamlessly span on premise andamp hosted cloud operating systems and vastly simplify data management andamp computation all while facilitating compliance with institutional policies and regulatory requirements PUBLIC HEALTH RELEVANCE The delivery of healthcare based on molecular data specific to an individual patient i e precision medicine will require the creation of a new ecosystem of Clinical Decision Support CDS applications This work will provide a platform that will make the development of such applications faster easier and less expensive