Development and Assessment of Video-Based Directly Observed Therapy for Tuberculosis

DESCRIPTION provided by applicant The Development and Assessment of Video Based Directly Observed Treatment for Tuberculosis TB is a project to develop a patient centered cost saving alternative strategy to ensure TB treatment completion TB disproportionately affects vulnerable populations and there are barriers to TB care `Directly observed therapyandapos DOT is the recommended standard for all TB patients to enhance adherence However DOT is labor intensive expensive and can be burdensome and stigmatizing for patients An alternative strategy is to view patients taking TB therapy `at a distanceandapos using video recorded at a patientandapos s convenience using mobile devices Videos are observed by clinicians to verify that medication was taken The small business emocha Mobile Health Inc and Johns Hopkins University have created a prototype called miDOT mobile internet DOT to allow video based DOT and TB monitoring This proposal will further product development to allow broad TB program implementation and commercialization with customization to reduce TB related health disparities Project sites include Public Health TB clinics in Baltimore City Baltimore County and Anne Arundel County Maryland In Aim we will conduct a baseline comprehensive needs assessment of TB patients and program staff The objective is to establish a software development plan by assessing technological readiness of TB programs and patients establish minimum infrastructure requirements and clinical systems integration needs and analyze logistical cultural and financial barriers to TB care that can be reduced using a video DOT approach In Aim an optimized product for video DOT and TB management will be developed The current prototype will be improved based on Aim data to create a `betaandapos miDOT version User testing of the `betaandapos application will be conducted among TB patients and staff to gather additional user feedback and guide further product optimization In Aim the optimized version of miDOT will be implemented in TB clinics to demonstrate effectiveness and to conduct a cost analysis In a pilot prospective study the proportion of expected doses of TB therapy that can be verified observed using miDOT will be compared to a cohort receiving standard DOT services In addition a cost analysis will assess the patient and health system costs associated with using miDOT compared to costs associated with standard DOT Patient and staff satisfaction with miDOT as an alternative to standard DOT services will be assessed Project success will be enhanced through strong collaborations between emocha Johns Hopkins University investigators and Public Health Department TB programs The investigative team has significant experience in product and business development TB clinical research public health and development and evaluation of mHealth interventions Completion of grant activities will lead to an optimized product to allow video based DOT that overcomes current health disparities in TB care PUBLIC HEALTH RELEVANCE The proposed study will develop and evaluate video based Directly Observed Treatment DOT strategies in Public Health Tuberculosis TB Clinics to improve care Video DOT offers the benefit of patient convenience potential for reduced stigma from a disease that disproportionately affects vulnerable populations and reduced health care staff time and expense The proposal will optimize a video based DOT platform and will evaluate the effectiveness and costs of video DOT as an alternative to conventional DOT