Dedicated Brain PET Device Optimized for Brain Imaging

DESCRIPTION provided by applicant Neurodegenerative diseases such as Alzheimer and other dementias present significant societal and economic burden The number of patients suffering from these disorders grows rapidly owing to the aging of the world population Alzheimerandapos s Association projects that the number of Americans living with Alzheimerandapos s disease AD will increase from M today to M in Management and treatment of brain disorders is a critical task facing the healthcare innovation system continuing progress in this field will depend on early high confidence diagnosis Amyloid imaging agents the new promising class of Positron Emission Tomography PET radiopharmaceuticals enable diagnosis of Alzheimerandapos s pathology at the early stages of disease Brain Biosciences seeks to make neurological PET imaging affordable and widely available both in the clinic and in the research laboratory To achieve this goal we aim to develop validate and obtain k FDA clearance for CerePETandquot a compact portable high performance and cost effective PET scanner for brain imaging This innovative device is designed to achieve high resolution at a fraction of the cost of currently marketed whole body PET systems CerePET applications include i evaluation of amyloid burden in patients with suspected Alzheimer disease mild cognitive impairment and other neurodegenerative disorders ii multicenter clinical trials of CNS targeted pharmaceuticals using PET scan as a biomarker iii clinical neuroscience research During this Fast track SBIR project CerePET will be rigorously validated using a set of internationally recognized tests CerePET imaging performance will be characterized per NEMA NU the scanner will be used in a clinical study comparing amyloid burden in patients with Alzheimerandapos s disease and healthy controls PUBLIC HEALTH RELEVANCE This application proposes to develop small footprint high performance Positron Emission Tomography PET scanner optimized for brain imaging This device will lower the cost and increase availability of neurological PET examinations both in the clinical and research settings